MCM21/YDR318W Summary

MCM21 BASIC INFORMATION

Standard Name	MCM21 1
Systematic Name	YDR318W
Alias	CTF5 2
Feature Type	ORF, Verified
Description	Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules (1, 3)
Name Description	MiniChromosome Maintenance 4

GO Annotations	All MCM21 GO evidence and references
	View Computational GO annotations for MCM21
Molecular Function
Manually curated	protein binding (IDA)
Biological Process
Manually curated	chromosome segregation (IPI) establishment of mitotic sister chromatid cohesion (IMP)
Cellular Component
Manually curated	COMA complex (IDA) condensed nuclear chromosome kinetochore (IDA)

Mutant Phenotype	All MCM21 Phenotype details and references
Classical genetics
null	chromosome/plasmid maintenance: abnormal colony sectoring: increased resistance to cincreasin: decreased resistance to bortezomib: decreased
Large-scale survey
null	chromosome/plasmid maintenance: decreased competitive fitness: decreased resistance to benomyl: decreased resistance to nickel sulfate: increased viable

Interactions	MCM21 All interactions details and references
	View additional details at BioGRID
	232 total interaction(s) for 117 unique genes/features.
Physical Interactions	Affinity Capture-MS: 23 Affinity Capture-Western: 13 Co-fractionation: 3 Two-hybrid: 10
Genetic Interactions	Dosage Lethality: 3 Dosage Rescue: 1 Negative Genetic: 115 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Positive Genetic: 5 Synthetic Growth Defect: 23 Synthetic Lethality: 33

Sequence Information

ChrIV:1103756 to 1104945 | |

Last Update

Coordinates: 2008-06-05 | Sequence: 2003-09-27

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..52	1103756..1103807	2008-06-05	2003-09-27
Intron	53..135	1103808..1103890	2008-06-05	2003-09-27
CDS	136..1190	1103891..1104945	2008-06-05	2003-09-27

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002726

MCM21 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MCM21

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MCM21]

1)	Poddar A, et al. (1999) MCM21 and MCM22, two novel genes of the yeast Saccharomyces cerevisiae are required for chromosome transmission. Mol Microbiol 31(1):349-60
2)	Spencer F, et al. (1990) Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124(2):237-49
3)	De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21
4)	Maine GT, et al. (1984) Mutants of S. cerevisiae defective in the maintenance of minichromosomes. Genetics 106(3):365-85

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