LYS4/YDR234W Summary Help

LYS4 BASIC INFORMATION

Standard Name LYS4
Systematic Name YDR234W
Alias LYS3
Feature Type ORF, Verified
Description Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway (1 and see Summary Paragraph)
Name Description LYSine requiring
GO Annotations All LYS4 GO evidence and references
    View Computational GO annotations for LYS4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Pathways
Mutant Phenotype All LYS4 Phenotype details and references
Large-scale survey
null
Interactions LYS4 All interactions details and references
  View additional details at BioGRID
19 total interaction(s) for 19 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Biochemical Activity: 1
Genetic Interactions
  • Synthetic Lethality: 11
Sequence Information
ChrIV:931126 to 933207 | ORF Map | GBrowse
Gbrowse
Genetic position: 145.87 cM
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2082 931126..933207 2008-06-05 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002642

LYS4 RESOURCES

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Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for LYS4

SUMMARY PARAGRAPH for LYS4

About lysine biosynthesis

S. cerevisiae synthesizes the essential amino acid L-lysine via the L-alpha-aminoadipic acid pathway instead of the diaminopmelate pathway (2). Originally proposed to be characteristic of fungi, recent studies suggest prokaryotes also synthesize lysine via the alpha-aminoadipic acid pathway (3). Intermediates in this pathway are often incorporated into secondary metabolites. For example, it has been well- studied that alpha-aminoadipate is required for penicillin production (2). Regulation of the lysine biosynthetic pathway in S. cerevisiae is an interaction between general amino acid control (via Gcn4p) (4), feedback inhibition of homocitrate synthase activity by lysine (5), and induction of Lys14p by alpha-aminoadipate semialdehyde (6).

Last updated: 2007-10-04

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for LYS4]

1) Maragoudakis ME and Strassman M  (1966) Homocitric acid accumulation by a lysine-requiring yeast mutant. J Biol Chem 241(3):695-9
2) Zabriskie TM and Jackson MD  (2000) Lysine biosynthesis and metabolism in fungi. Nat Prod Rep 17(1):85-97
3) Nishida H and Nishiyama M  (2000) What is characteristic of fungal lysine synthesis through the alpha-aminoadipate pathway? J Mol Evol 51(3):299-302
4) Hinnebusch A  (1992) "General and Pathway-specific Regulatory Mechanisms Controlling the Synthesis of Amino Acid Biosynthetic Enzymes in Saccharomyces cerevisiae". Pp. 319-414 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
5) Feller A, et al.  (1999) In Saccharomyces cerevisae, feedback inhibition of homocitrate synthase isoenzymes by lysine modulates the activation of LYS gene expression by Lys14p. Eur J Biochem 261(1):163-70
6) El Alami M, et al.  (2000) Characterisation of a tripartite nuclear localisation sequence in the regulatory protein Lys14 of Saccharomyces cerevisiae. Curr Genet 38(2):78-86