ADK1/YDR226W Summary

ADK1 BASIC INFORMATION

Standard Name	ADK1 1
Systematic Name	YDR226W
Alias	AKY1 , AKY2 2 , 3
Feature Type	ORF, Verified
Description	Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence (1, 4, 5)
Name Description	ADenylate Kinase 1

GO Annotations	All ADK1 GO evidence and references
	View Computational GO annotations for ADK1
Molecular Function
Manually curated	adenylate kinase activity (IDA, IMP)
Biological Process
Manually curated	ADP biosynthetic process (IDA) nucleotide metabolic process (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) mitochondrial intermembrane space (IDA)
High-throughput	mitochondrion (IDA)

Pathways	de novo biosynthesis of purine nucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All ADK1 Phenotype details and references
Classical genetics
null	glycerol accumulation: increased ethanol accumulation: increased ATP accumulation: decreased ADP accumulation: decreased AMP accumulation: increased IMP accumulation: increased inosine accumulation: increased hypoxanthine accumulation: increased chromosome/plasmid maintenance: abnormal growth in exponential phase: decreased rate metal resistance: decreased respiratory metabolism: increased utilization of carbon source: increased utilization of carbon source: absent vegetative growth: decreased viable
Large-scale survey
null	bud morphology: abnormal glycogen accumulation: increased competitive fitness: decreased heat sensitivity: increased lipid particle morphology: abnormal metal resistance: decreased resistance to L-1,4-dithiothreitol: decreased resistance to caffeine: decreased resistance to hygromycin B: decreased resistance to sulfanilamide: decreased resistance to doxorubicin: decreased resistance to hydroxyurea: increased respiratory growth: absent toxin resistance: decreased utilization of phosphorus source: decreased viable

Interactions	ADK1 All interactions details and references
	24 total interaction(s) for 23 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 1 Biochemical Activity: 7 PCA: 1
Genetic Interactions	Dosage Rescue: 1 Phenotypic Suppression: 1 Synthetic Growth Defect: 1

Sequence Information

ChrIV:916483 to 917151 | |

Genetic position: 133 cM

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..669	916483..917151	2008-06-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002634

ADK1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ADK1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ADK1]

1)	Konrad M (1988) Analysis and in vivo disruption of the gene coding for adenylate kinase (ADK1) in the yeast Saccharomyces cerevisiae. J Biol Chem 263(36):19468-74
2)	Oechsner U, et al. (1988) Yeast adenylate kinase is transcribed constitutively from a promoter in the short intergenic region to the histone H2A-1 gene. FEBS Lett 242(1):187-93
3)	Schricker R, et al. (2002) Redundant mitochondrial targeting signals in yeast adenylate kinase. J Biol Chem 277(32):28757-64
4)	Klier H, et al. (1996) Cytoplasmic and mitochondrial forms of yeast adenylate kinase 2 are N-acetylated. Biochim Biophys Acta 1280(2):251-6
5)	Rebora K, et al. (2001) Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate. Mol Cell Biol 21(23):7901-12

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