RBK1/YCR036W Summary Help

RBK1 BASIC INFORMATION

Standard Name RBK1
Systematic Name YCR036W
Feature Type ORF, Verified
Description Putative ribokinase (1 and see Summary Paragraph)
Name Description RiBoKinase 1
GO Annotations All RBK1 GO evidence and references
    View Computational GO annotations for RBK1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant Phenotype All RBK1 Phenotype details and references
Large-scale survey
null
Interactions RBK1 All interactions details and references
  View additional details at BioGRID
29 total interaction(s) for 29 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Two-hybrid: 1
Genetic Interactions
  • Negative Genetic: 23
  • Positive Genetic: 1
  • Synthetic Growth Defect: 2
Sequence Information
ChrIII:193293 to 194294 | ORF Map | GBrowse
Gbrowse
Genetic position: 29 cM
Last Update Coordinates: 2006-01-12 | Sequence: 2000-09-13
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1002 193293..194294 2006-01-12 2000-09-13
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000632

RBK1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for RBK1

SUMMARY PARAGRAPH for RBK1

RBK1 encodes a putative ribokinase (EC: 2.7.1.15) predicted to be involved in ribose metabolism (1). Rbk1p has two regions of similarity to human ADK (OMIM), E. coli ribokinase, and the fructokinases from Kiebsiella, Salmonella, Vibrio, Rhizobium and potato, and has one region of similarity to E. coli inosine kinase and deoxygluconokinase (2, 1). Rbk1p localizes to the nucleus and cytoplasm (3).

rbk1 null mutants are viable and exhibit increased glycogen accumulation, as determined by iodine staining (4, 5). An active autonomously replicating sequence, ARS313, is located in the vicinity of RBK1 and hinders the isolation of an integrative disruption mutant (1).

Last updated: 2005-12-13

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RBK1]

1) Thierry A, et al.  (1990) The complete sequence of the 8.2 kb segment left of MAT on chromosome III reveals five ORFs, including a gene for a yeast ribokinase. Yeast 6(6):521-34
2) Spychala J, et al.  (1996) Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases. Proc Natl Acad Sci U S A 93(3):1232-7
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
5) Wilson WA, et al.  (2002) Systematic identification of the genes affecting glycogen storage in the yeast Saccharomyces cerevisiae: implication of the vacuole as a determinant of glycogen level. Mol Cell Proteomics 1(3):232-42