EXO5/YBR163W Summary

EXO5 BASIC INFORMATION

Standard Name	EXO5 1, 2
Systematic Name	YBR163W
Alias	DEM1 3
Feature Type	ORF, Verified
Description	Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 (2, 3, 4, 5)
Name Description	EXOnuclease V 2

GO Annotations	All EXO5 GO evidence and references
	View Computational GO annotations for EXO5
Molecular Function
Manually curated	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity (IDA)
Biological Process
Manually curated	mitochondrial genome maintenance (IMP)
Cellular Component
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All EXO5 Phenotype details and references
Classical genetics
null	mitochondrial rho- mutation frequency: increased nuclear morphology: abnormal respiratory metabolism: absent vacuolar morphology: abnormal
Large-scale survey
null	glycogen accumulation: decreased glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased mitochondrial genome maintenance: abnormal mitochondrial morphology: abnormal resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to trichothecene: increased respiratory growth: decreased rate respiratory growth: absent utilization of carbon source: decreased viable

Interactions	EXO5 All interactions details and references
	View additional details at BioGRID
	2 total interaction(s) for 2 unique genes/features.
Genetic Interactions	Synthetic Haploinsufficiency: 1 Synthetic Lethality: 1

Sequence Information

ChrII:565718 to 567475 | |

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1758	565718..567475	2004-07-16	1997-01-28

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000367

EXO5 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for EXO5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for EXO5]

1)	Burgers PM, et al. (1988) Exonuclease V from Saccharomyces cerevisiae. A 5'----3'-deoxyribonuclease that produces dinucleotides in a sequential fashion. J Biol Chem 263(17):8099-105
2)	Burgers PM, et al. (2010) Yeast exonuclease 5 is essential for mitochondrial genome maintenance. Mol Cell Biol 30(6):1457-66
3)	Entian KD, et al. (1999) Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet 262(4-5):683-702
4)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5)	Sun W, et al. (2007) Detection of eQTL modules mediated by activity levels of transcription factors. Bioinformatics 23(17):2290-7

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