TAL1/YLR354C Summary Help

TAL1 BASIC INFORMATION

Standard Name TAL1 1
Systematic Name YLR354C
Feature Type ORF, Verified
Description Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate (1 and see Summary Paragraph)
Name Description TransALdolase 1
GO Annotations All TAL1 GO evidence and references
    View Computational GO annotations for TAL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Pathways
Mutant Phenotype All TAL1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
Interactions TAL1 All interactions details and references
23 total interaction(s) for 19 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-RNA: 1
Genetic Interactions
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 6
  • Synthetic Rescue: 1
Sequence Information
ChrXII:837356 to 836349 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1008 837356..836349 2004-02-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004346

TAL1 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for TAL1

SUMMARY PARAGRAPH for TAL1

Tal1p is a transaldolase (EC 2.2.1.2) that is important for the non-oxidative branch of the pentose phosphate pathway (2) and is located in the cytosol (3). Lysine144 is essential for the catalytic activity of Tal1p (2). TAL1 encodes the only transaldolase in yeast, but is not an essential gene (1). Null mutants for tal1 accumulate sedoheptulose 7-phosphate, which is an intermediate of the pentose-phosphate pathway (1) and display increased sensitivity to hydrogen peroxide (4). TAL1 appears to be constitutively expressed under most conditions (1), but is repressed in response to dimethyl sulfoxide (DMSO) (5), and is induced in response to hydrogen peroxide in a Yap1p-dependent manner (4). It is also induced in response to xylose in a strain engineered to utilize xylose (6). Tal1p is of industrial interest because overproduction of Tal1p enhances the growth of recombinant S. cerevisiae strains engineered to ferment xylose (the major pentose in lignocellulose) to ethanol (7).

Tal1p has similarity to human TALDO1 (OMIM; 8), Candida utilis transaldolase (1) and Kluyveromyces lactis KITAL1, which can complement the transaldolase deficiency of tal1 null mutants (9).

Last updated: 2005-12-21

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TAL1]

1) Schaaff I, et al.  (1990) Molecular analysis of the structural gene for yeast transaldolase. Eur J Biochem 188(3):597-603
2) Miosga T, et al.  (1993) Lysine144 is essential for the catalytic activity of Saccharomyces cerevisiae transaldolase. Yeast 9(11):1241-9
3) Maaheimo H, et al.  (2001) Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional (13)C labeling of common amino acids. Eur J Biochem 268(8):2464-79
4) Lee J, et al.  (1999) Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast. J Biol Chem 274(23):16040-6
5) Zhang W, et al.  (2003) Microarray analyses of the metabolic responses of Saccharomyces cerevisiae to organic solvent dimethyl sulfoxide. J Ind Microbiol Biotechnol 30(1):57-69
6) Toivari MH, et al.  (2004) Endogenous xylose pathway in Saccharomyces cerevisiae. Appl Environ Microbiol 70(6):3681-6
7) Walfridsson M, et al.  (1995) Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolase. Appl Environ Microbiol 61(12):4184-90
8) Banki K, et al.  (1994) Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence. J Biol Chem 269(4):2847-51
9) Jacoby J, et al.  (1993) Transaldolase mutants in the yeast Kluyveromyces lactis provide evidence that glucose can be metabolized through the pentose phosphate pathway. Mol Microbiol 10(4):867-76