TEL06L Summary Help

Systematic Name TEL06L
Feature Type telomere
Description Telomeric region on the left arm of Chromosome VI; composed of an X element core sequence, X element combinatorial repeats, a stretch of telomeric repeats, and a short Y' element (1, 2 and see Summary Paragraph)
Chromosomal Location
ChrVI:5530 to 1 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -60 cM
sequence information
ChrVI:5530 to 1 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): YFL063W | YFL064C | YFL065C | YFL066C | YFL067W | YFL068W | TEL06L-TR | TEL06L-XC | TEL06L-XR | TEL06L-YP
Genetic position: -60 cM
Last Update Coordinates: 2003-09-09 | Sequence: 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
External Links All Associated Seq | Search all NCBI (Entrez)
Primary SGDIDS000028882

The chromosome ends of Saccharomyces cerevisiae are complex mosaics of several different types of telomeric and subtelomeric elements known as X element core sequences, X element combinatorial repeats, telomeric repeats, and Y' elements (2). The X element core sequence, a small conserved element of ~475 bp containing an ARS sequence and in most cases an Abf1p binding site, is the only region shared by all chromosome ends (2, 1). The X element combinatorial repeats, formerly known as subtelomeric repeats or STRs, are located between the X element core sequence and the telomeric end and are usually present as a combination of one or more of several types of smaller elements designated D, C, B, or A (2, 1). The telomeric repeat is a G-rich terminal sequence of the form (TG1-3)n that is maintained by telomerase (1). The Y' element is a helicase-encoding repetitive sequence found in many but not all subtelomeric regions next to the telomeric repeats, or adjacent X element combinatorial repeats, either as a single copy or tandem repeat of two to four copies (3, 1, 4). Possible functions of telomeric regions include roles in chromosomal segregation, maintenance of chromosome stability, recombinational sequestering, or as a barrier to transcriptional silencing (2, 1).

TEL06L, the left telomeric region of chromosome VI, is composed of an X element core sequence TEL06L-XC containing an ARS consensus sequence, an ABf1p binding site and a dubious ORF YFL063W, X element combinatorial repeats TEL06L-XR of the D, C, B and A types containing TBf1p binding sites, a stretch of telomeric repeats TEL06L-TR, and a short Y' (Y'-S) element TEL06L-YP containing a region of 36-bp repeats and five uncharacterized ORFs (YFL064C, YFL065C, YFL066C, YFL067W and YFL068W).

Click on the following figure for more details:

telomere map

Further information can be found at the website of Dr. Ed Louis, Institute of Genetics, The University of Nottingham.

Last updated: 2003-10-29 Contact SGD

References cited on this page View Complete Literature Guide for TEL06L
1) Louis EJ  (1995) The chromosome ends of Saccharomyces cerevisiae. Yeast 11(16):1553-73
2) Louis EJ, et al.  (1994) The chromosome end in yeast: its mosaic nature and influence on recombinational dynamics. Genetics 136(3):789-802
3) Louis EJ and Haber JE  (1992) The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisiae. Genetics 131(3):559-74
4) Yamada M, et al.  (1998) Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. J Biol Chem 273(50):33360-6