GPI2/YPL076W Summary Help

Standard Name GPI2 1
Systematic Name YPL076W
Alias GCR4 2
Feature Type ORF, Verified
Description Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol (1, 3)
Name Description GlycosylPhosphatidylInositol anchor biosynthesis 1
Chromosomal Location
ChrXVI:410443 to 411285 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GPI2 GO evidence and references
  View Computational GO annotations for GPI2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
conditional
null
reduction of function
Large-scale survey
null
overexpression
reduction of function
Resources
106 total interaction(s) for 102 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • PCA: 61

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 28
  • Positive Genetic: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 280
Molecular Weight (Da) 32,577
Isoelectric Point (pI) 10.24
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:410443 to 411285 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..843 410443..411285 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005997
References cited on this page View Complete Literature Guide for GPI2
1) Leidich SD, et al.  (1995) Temperature-sensitive yeast GPI anchoring mutants gpi2 and gpi3 are defective in the synthesis of N-acetylglucosaminyl phosphatidylinositol. Cloning of the GPI2 gene. J Biol Chem 270(22):13029-35
2) Uemura H and Jigami Y  (1995) A new essential gene GCR4 located in the upstream region of GCR1. Yeast 11(11):1093-101
3) Inoue N, et al.  (1996) PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2. Biochem Biophys Res Commun 226(1):193-9