CTR9/YOL145C Summary Help

Standard Name CTR9 1
Systematic Name YOL145C
Alias CDP1 2
Feature Type ORF, Verified
Description Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats (3, 4, 5, 6, 7)
Name Description Cln Three (CLN3) Requiring 1
Chromosomal Location
ChrXV:52788 to 49555 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CTR9 GO evidence and references
  View Computational GO annotations for CTR9
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 11 genes
Regulators 1 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
268 total interaction(s) for 172 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 90
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 21
  • Co-purification: 1
  • PCA: 1
  • Protein-RNA: 4
  • Two-hybrid: 12

Genetic Interactions
  • Negative Genetic: 50
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 2
  • Positive Genetic: 52
  • Synthetic Growth Defect: 17
  • Synthetic Lethality: 9
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,077
Molecular Weight (Da) 124,709
Isoelectric Point (pI) 6.23
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:52788 to 49555 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3234 52788..49555 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005505
References cited on this page View Complete Literature Guide for CTR9
1) Di Como CJ, et al.  (1995) Activation of CLN1 and CLN2 G1 cyclin gene expression by BCK2. Mol Cell Biol 15(4):1835-46
2) Foreman PK and Davis RW  (1996) CDP1, a novel Saccharomyces cerevisiae gene required for proper nuclear division and chromosome segregation. Genetics 144(4):1387-97
3) Koch C, et al.  (1999) A role for Ctr9p and Paf1p in the regulation G1 cyclin expression in yeast. Nucleic Acids Res 27(10):2126-34
4) Mueller CL and Jaehning JA  (2002) Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex. Mol Cell Biol 22(7):1971-80
5) Zhang Y, et al.  (2009) The Paf1 complex is required for efficient transcription elongation by RNA polymerase I. Proc Natl Acad Sci U S A 106(7):2153-8
6) Tous C, et al.  (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64
7) Pruneski JA, et al.  (2011) The Paf1 complex represses SER3 transcription in Saccharomyces cerevisiae by facilitating intergenic transcription-dependent nucleosome occupancy of the SER3 promoter. Eukaryot Cell 10(10):1283-94