GIN4/YDR507C Summary Help

Standard Name GIN4 1
Systematic Name YDR507C
Alias ERC47
Feature Type ORF, Verified
Description Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Growth Inhibitory 1
Chromosomal Location
ChrIV:1465786 to 1462358 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All GIN4 GO evidence and references
  View Computational GO annotations for GIN4
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulators 12 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
Resources
409 total interaction(s) for 257 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 44
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 25
  • Biochemical Activity: 9
  • PCA: 11
  • Reconstituted Complex: 26
  • Two-hybrid: 19

Genetic Interactions
  • Dosage Growth Defect: 110
  • Dosage Lethality: 1
  • Dosage Rescue: 4
  • Negative Genetic: 112
  • Phenotypic Enhancement: 15
  • Phenotypic Suppression: 2
  • Positive Genetic: 3
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 15
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,142
Molecular Weight (Da) 129,857
Isoelectric Point (pI) 10
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1465786 to 1462358 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3429 1465786..1462358 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002915
References cited on this page View Complete Literature Guide for GIN4
1) Altman R and Kellogg D  (1997) Control of mitotic events by Nap1 and the Gin4 kinase. J Cell Biol 138(1):119-30
2) Okuzaki D, et al.  (2003) The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions. Genes Genet Syst 78(2):113-26
3) Iwase M and Toh-E A  (2004) Ybr267w is a new cytoplasmic protein belonging to the mitotic signaling network of Saccharomyces cerevisiae. Cell Struct Funct 29(1):1-15
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61