ASP1/YDR321W Summary Help

Standard Name ASP1 1
Systematic Name YDR321W
Feature Type ORF, Verified
Description Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively (1, 2)
Name Description ASParaginase 1
Chromosomal Location
ChrIV:1108702 to 1109847 | ORF Map | GBrowse
Gbrowse
Genetic position: 190 cM
Gene Ontology Annotations All ASP1 GO evidence and references
  View Computational GO annotations for ASP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Pathways
Large-scale survey
null
Resources
22 total interaction(s) for 19 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 3
  • PCA: 2
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 9
  • Positive Genetic: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 381
Molecular Weight (Da) 41,395
Isoelectric Point (pI) 5.16
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1108702 to 1109847 | ORF Map | GBrowse
SGD ORF map
Genetic position: 190 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1146 1108702..1109847 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002729
References cited on this page View Complete Literature Guide for ASP1
1) Sinclair K, et al.  (1994) The ASP1 gene of Saccharomyces cerevisiae, encoding the intracellular isozyme of L-asparaginase. Gene 144(1):37-43
2) Cooper TG  (1982) "Nitrogen metabolism in Saccharomyces cerevisiae." Pp. 39-99 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press