MPR1 Summary Help

Standard Name MPR1 1
Feature Type not in systematic sequence of S288C
Description L-azetidine-2-carboxylic acid acetyltransferase; reduces intracellular ROS and contributes to L-proline analog resistance and tolerance to ethanol and freezing; member of N-acetyltransferase superfamily; not found in S288C, only present in strains with Sigma1278b background; located on left arm of chromosome XIV approximately 15 kb from telomere (1, 2, 3, 4)
Name Description sigMa 1278b gene for l-Proline-analogue Resistance 1
Gene Ontology Annotations All MPR1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
gain of function
reduction of function
External Links All Associated Seq | Search all NCBI (Entrez)
Primary SGDIDS000029666
References cited on this page View Complete Literature Guide for MPR1
1) Takagi H, et al.  (2000) Saccharomyces cerevisiae sigma 1278b has novel genes of the N-acetyltransferase gene superfamily required for L-proline analogue resistance. J Bacteriol 182(15):4249-56
2) Shichiri M, et al.  (2001) A novel acetyltransferase found in Saccharomyces cerevisiae Sigma1278b that detoxifies a proline analogue, azetidine-2-carboxylic acid. J Biol Chem 276(45):41998-2002
3) Du X and Takagi H  (2005) N-acetyltransferase Mpr1 confers freeze tolerance on Saccharomyces cerevisiae by reducing reactive oxygen species. J Biochem (Tokyo) 138(4):391-7
4) Du X and Takagi H  (2007) N-Acetyltransferase Mpr1 confers ethanol tolerance on Saccharomyces cerevisiae by reducing reactive oxygen species. Appl Microbiol Biotechnol 75(6):1343-51