MPR1 Summary 
| Standard Name | MPR1 1 (see Nomenclature conflict Note) |
|---|---|
| Feature Type | not in systematic sequence of S288C |
| Description | L-azetidine-2-carboxylic acid acetyltransferase; reduces intracellular ROS and contributes to L-proline analog resistance and tolerance to ethanol and freezing; member of N-acetyltransferase superfamily; not found in S288C, only present in strains with Sigma1278b background; located on left arm of chromosome XIV approximately 15 kb from telomere (1, 2, 3, 4) |
| Name Description | sigMa 1278b gene for Proline-analogue Resistance 1 |
Gene Ontology Annotations All MPR1 GO evidence and references
| Molecular Function | |
|---|---|
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
|
Mutant phenotypes All MPR1 Phenotype evidence and references
| Classical genetics | |
|---|---|
| gain of function | |
| null |
Resources
| External Links | All Associated Seq | Search all NCBI (Entrez) |
|---|
| Primary SGDID | S000029666 |
|---|
NOMENCLATURE CONFLICT NOTE
| Name | Relevance | Description |
|---|---|---|
| RPN11 | Nomenclature conflict | Do not confuse RPN11/MPR1/YFR004W, a multicatalytic endopeptidase, with the MPR1 that encodes an N-acetyltransferase. Both have been referred to as MPR1. Note that the N-acetyltransferase is not present in the S288C strain. |
References cited on this page View Complete Literature Guide for MPR1
| 1) | Shichiri M, et al. (2001) A novel acetyltransferase found in Saccharomyces cerevisiae Sigma1278b that detoxifies a proline analogue, azetidine-2-carboxylic acid. J Biol Chem 276(45):41998-2002 |
| 2) | Takagi H, et al. (2000) Saccharomyces cerevisiae sigma 1278b has novel genes of the N-acetyltransferase gene superfamily required for L-proline analogue resistance. J Bacteriol 182(15):4249-56 |
| 3) | Du X and Takagi H (2005) N-acetyltransferase Mpr1 confers freeze tolerance on Saccharomyces cerevisiae by reducing reactive oxygen species. J Biochem 138(4):391-7 |
| 4) | Du X and Takagi H (2007) N-Acetyltransferase Mpr1 confers ethanol tolerance on Saccharomyces cerevisiae by reducing reactive oxygen species. Appl Microbiol Biotechnol 75(6):1343-51 |
