SUC7 Summary Help

SUC7 BASIC INFORMATION

Standard Name SUC7 1
Feature Type not in systematic sequence of S288C
Description Invertase, sucrose hydrolyzing enzyme; six related but non-identical invertase genes have been described in yeasat (SUC1-5, 7) but only SUC2 is in strain S288C; unlike the other forms of invertase, Suc7p is unable to hydrolyze raffinose (2, 3, 4 and see Summary Paragraph)
GO Annotations All SUC7 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Primary SGDIDS000029535

SUC7 RESOURCES

  • Literature

ADDITIONAL INFORMATION for SUC7

SUMMARY PARAGRAPH for SUC7

The S. cerevisiae genome contains six unlinked loci that encode invertase: SUC1, SUC2, SUC3, SUC4, SUC5, and SUC7 (3). This enzyme, also known as "beta-fructofuranosidase," "beta-fructosidase," or "sucrase," plays an important role in sugar metabolism. Invertase catalyzes the hydrolysis of both the disaccharide sucrose (producing the monosaccharides fructose and glucose) and the trisaccharide raffinose (producing fructose and melibiose) (4, 5). All invertase genes except SUC2 are located within telomere sequences (6). Although individual strains may carry any number and combination of SUC genes, the reference strain (S288C) encodes only SUC2 (3) and most recent studies on invertase have focused on that gene.

Invertase played a notable role in early research on basic enzyme function. The colloquial name "invertase" comes from the fact that a solution of sucrose polarizes light in the opposite direction from an equimolar solution of glucose + fructose. This "inversion" of sugar provided a straightforward functional assay which, along with the easy preparation of a periplasmic protein (7 and references therein), made invertase a popular research subject among early biochemists. Many seminal works defining and describing enzymes, including those of Adrian Brown (8) and Leonor Michaelis and Maude Menton (9), focused on invertase.

Invertase also has a role in the food industry where it is used to produce fructose for use in confectionary. Fructose is often preferred over sucrose in candies with soft centers, as it is sweeter and less prone to crystallization (10).

Last updated: 2007-05-23

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SUC7]

1) Celenza, J. and Carlson, M.  (1989) Personal Communication, Mortimer Map Edition 10
2) Carlson M, et al.  (1981) Genetic evidence for a silent SUC gene in yeast. Genetics 98(1):41-54
3) Carlson M and Botstein D  (1983) Organization of the SUC gene family in Saccharomyces. Mol Cell Biol 3(3):351-9
4) Gascon S, et al.  (1968) Comparative study of the properties of the purified internal and external invertases from yeast. J Biol Chem 243(7):1573-7
5) Taussig R and Carlson M  (1983) Nucleotide sequence of the yeast SUC2 gene for invertase. Nucleic Acids Res 11(6):1943-54
6) Carlson M, et al.  (1985) Evolution of the dispersed SUC gene family of Saccharomyces by rearrangements of chromosome telomeres. Mol Cell Biol 5(11):2894-902
7) O'Sullivan C and Tompson F  (1890) LX.-Invertase: a contribution to the history of an enzyme or unorganised ferment J Chem Soc Trans 57:834-931
8) Brown A  (1902) Enzyme action J Chem Soc Trans 81:373-388
9) Michaelis L and Menten M  (1913) Kinetik der Invertinwirkung Biochem Z 49:333-369
10) Smith J and Hong-Shum L  (2003) Food Additives Data Book :432