SUMMARY PARAGRAPH for TEL12R-YP2
TEL12R-YP2, the more centromere-proximal of two long Y' (Y'-L) elements on the right arm of chromosome XII, contains an ARS consensus sequence, a region of 36-bp repeats, one verified ORF YRF1-4/YLR466W, two uncharacterized ORFs (YLR462W, YLR464W), part of a third uncharacterized ORF YLR466C-B, and two dubious ORFs (YLR463C, BSC3/YLR465C).
The Y' element is a repetitive sequence found in many but not all subtelomeric regions next to the telomeric repeats, or adjacent X element combinatorial repeats, either as a single copy or tandem repeat of two to four copies (2, 3). Two main types of Y' elements are known, Y'-L and Y'-S, and any particular array will consist of only one type, not a combination of both (1). Y' elements contain helicase-encoding ORFs which are expressed only during meiosis and in telomerase-deficient cells (1). Possible functions include rescue of telomeres when the telomeric repeats are no longer present and a role in telomere maintenance during meiosis (1).
Other features of TEL12R, the right telomeric region of chromosome XII, include an X element core sequence TEL12R-XC, a region of X element combinatorial repeats TEL12R-XR, two stretches of telomeric repeats (TEL12R-TR1, TEL12R-TR2), and an additional Y' element TEL12L-YP1.
Click on the following figure for more details:
Further information can be found at the website of Dr. Ed Louis, Institute of Genetics, The University of Nottingham.
Last updated: 2003-11-18