TEL12R-YP2 Summary Help

Systematic Name TEL12R-YP2
Feature Type Y'_element
Description Long telomeric Y' element on the right arm of Chromosome XII; more centromere-proximal of two long telomeric Y' elements; contains an ARS consensus sequence, a region of 36-bp repeats, 5 ORFs (YLR466W, YLR462W, YLR464W, YLR463C, YLR465C), and part of ORF YLR466C-B (1, 2, 3 and see Summary Paragraph)
Chromosomal Location
ChrXII:1065156 to 1071645 | ORF Map | GBrowse
sequence information
ChrXII:1065156 to 1071645 | ORF Map | GBrowse
This feature contains embedded feature(s): YLR462W | YLR463C | YLR464W | BSC3 | YRF1-4 | YLR466C-A
This feature is contained within: TEL12R
Last Update Coordinates: 2011-02-03 | Sequence: 2003-09-09
Subfeature details
Most Recent Updates
Coordinates Sequence
Repeat region 4450..4876 1069605..1070031 2011-02-03 2003-09-09
ACS 6269..6279 1071424..1071434 2011-02-03 2003-09-09
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
External Links All Associated Seq | Search all NCBI (Entrez)
Primary SGDIDS000028988

TEL12R-YP2, the more centromere-proximal of two long Y' (Y'-L) elements on the right arm of chromosome XII, contains an ARS consensus sequence, a region of 36-bp repeats, one verified ORF YRF1-4/YLR466W, two uncharacterized ORFs (YLR462W, YLR464W), part of a third uncharacterized ORF YLR466C-B, and two dubious ORFs (YLR463C, BSC3/YLR465C).

The Y' element is a repetitive sequence found in many but not all subtelomeric regions next to the telomeric repeats, or adjacent X element combinatorial repeats, either as a single copy or tandem repeat of two to four copies (2, 3). Two main types of Y' elements are known, Y'-L and Y'-S, and any particular array will consist of only one type, not a combination of both (1). Y' elements contain helicase-encoding ORFs which are expressed only during meiosis and in telomerase-deficient cells (1). Possible functions include rescue of telomeres when the telomeric repeats are no longer present and a role in telomere maintenance during meiosis (1).

Other features of TEL12R, the right telomeric region of chromosome XII, include an X element core sequence TEL12R-XC, a region of X element combinatorial repeats TEL12R-XR, two stretches of telomeric repeats (TEL12R-TR1, TEL12R-TR2), and an additional Y' element TEL12L-YP1.

Click on the following figure for more details:

telomere map

Further information can be found at the website of Dr. Ed Louis, Institute of Genetics, The University of Nottingham.

Last updated: 2003-11-18 Contact SGD

References cited on this page View Complete Literature Guide for TEL12R-YP2
1) Yamada M, et al.  (1998) Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. J Biol Chem 273(50):33360-6
2) Louis EJ and Haber JE  (1992) The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisiae. Genetics 131(3):559-74
3) Pryde FE, et al.  (1997) Chromosome ends: all the same under their caps. Curr Opin Genet Dev 7(6):822-8