TEL05R Summary Help

Systematic Name TEL05R
Feature Type telomere
Description Telomeric region on the right arm of Chromosome V; annotated components include an X element core sequence, X element combinatorial repeats, and a long Y' element; TEL05R does have telomeric repeats (TEL05R-TR), but they are missing from the genome annotation due to difficulties encountered during sequencing and/or assembly (1, 2 and see Summary Paragraph)
Chromosomal Location
ChrV:569599 to 576874 | ORF Map | GBrowse
Genetic position: 151 cM
sequence information
ChrV:569599 to 576874 | ORF Map | GBrowse
This feature contains embedded feature(s): YER189W | YRF1-2 | YER190C-A | YER190C-B | YER188C-A | TEL05R-XC | TEL05R-XR | TEL05R-YP
Genetic position: 151 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2003-09-09
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S288C vs. other species
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Primary SGDIDS000028953

The chromosome ends of Saccharomyces cerevisiae are complex mosaics of several different types of telomeric and subtelomeric elements known as X element core sequences, X element combinatorial repeats, telomeric repeats, and Y' elements (2). The X element core sequence, a small conserved element of ~475 bp containing an ARS sequence and in most cases an Abf1p binding site, is the only region shared by all chromosome ends (2, 1). The X element combinatorial repeats, formerly known as subtelomeric repeats or STRs, are located between the X element core sequence and the telomeric end and are usually present as a combination of one or more of several types of smaller elements designated D, C, B, or A (2, 1). The telomeric repeat is a G-rich terminal sequence of the form (TG1-3)n that is maintained by telomerase (1). The Y' element is a helicase-encoding repetitive sequence found in many but not all subtelomeric regions next to the telomeric repeats, or adjacent X element combinatorial repeats, either as a single copy or tandem repeat of two to four copies (3, 1, 4). Possible functions of telomeric regions include roles in chromosomal segregation, maintenance of chromosome stability, recombinational sequestering, or as a barrier to transcriptional silencing (2, 1).

TEL05R, the right telomeric region of chromosome V, is composed of an X element core sequence TEL05R-XC containing an ARS consensus sequence, an ABf1p binding site and an uncharacterized ORF YER188C-A, X element combinatorial repeats TEL05R-XR of the D, C, B and A types containing Tbf1p binding sites, and a long Y' (Y'-L) element TEL05R-YP containing an ARS consensus sequence, a region of 36-bp repeats, one verified ORF YRF1-2/YER190W, one uncharacterized ORF YER189W and two dubious ORFs (YER190C-A and YER190C-B).

Click on the following figure for more details:

telomere map

Further information can be found at the website of Dr. Ed Louis, Institute of Genetics, The University of Nottingham.

Last updated: 2003-10-29 Contact SGD

References cited on this page View Complete Literature Guide for TEL05R
1) Louis EJ  (1995) The chromosome ends of Saccharomyces cerevisiae. Yeast 11(16):1553-73
2) Louis EJ, et al.  (1994) The chromosome end in yeast: its mosaic nature and influence on recombinational dynamics. Genetics 136(3):789-802
3) Louis EJ and Haber JE  (1992) The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisiae. Genetics 131(3):559-74
4) Yamada M, et al.  (1998) Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. J Biol Chem 273(50):33360-6