ERI1/YPL096C-A Summary Help

Standard Name ERI1 1
Systematic Name YPL096C-A
Alias RIN1
Feature Type ORF, Verified
Description Endoplasmic reticulum membrane protein that binds and inhibits Ras2p; binds to and inhibits GTP-bound Ras2p at the endoplasmic reticulum (ER); component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein (1, 2)
Name Description ER-associated Ras Inhibitor 1
Chromosomal Location
ChrXVI:366735 to 366529 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ERI1 GO evidence and references
  View Computational GO annotations for ERI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
57 total interaction(s) for 55 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 50
  • Positive Genetic: 1
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 68
Molecular Weight (Da) 8,039
Isoelectric Point (pI) 4.76
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:366735 to 366529 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2002-06-20
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..207 366735..366529 2011-02-03 2002-06-20
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000028423
References cited on this page View Complete Literature Guide for ERI1
1) Sobering AK, et al.  (2003) A novel Ras inhibitor, Eri1, engages yeast Ras at the endoplasmic reticulum. Mol Cell Biol 23(14):4983-90
2) Murakami Y, et al.  (2005) The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. Mol Biol Cell 16(11):5236-46