SDH6/YDR379C-A Summary Help

Standard Name SDH6 1
Systematic Name YDR379C-A
Feature Type ORF, Verified
Description Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; member of the LYR protein family; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy (1, 2)
Chromosomal Location
ChrIV:1233517 to 1233278 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SDH6 GO evidence and references
  View Computational GO annotations for SDH6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 9 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
2 total interaction(s) for 2 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 79
Molecular Weight (Da) 9,352
Isoelectric Point (pI) 10.89
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1233517 to 1233278 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2001-02-26
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..240 1233517..1233278 2011-02-03 2001-02-26
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007605
References cited on this page View Complete Literature Guide for SDH6
1) Na U, et al.  (2014) The LYR Factors SDHAF1 and SDHAF3 Mediate Maturation of the Iron-Sulfur Subunit of Succinate Dehydrogenase. Cell Metab ()
2) Ghezzi D, et al.  (2009) SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy. Nat Genet 41(6):654-6