YDR379C-A Summary

YDR379C-A Summary

Reserved Name	SDH6 1 This name is reserved with SGD according to the Gene Naming Guidelines agreed upon by the yeast community. For more information about this reservation, please see the Locus History.
Systematic Name	YDR379C-A
Feature Type	ORF, Verified
Description	Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy (1)

Chromosomal Location	ChrIV:1233517 to 1233278 \| ORF Map \| GBrowse
	Note: this feature is encoded on the Crick strand.

Gene Ontology Annotations All YDR379C-A GO evidence and references

	View Computational GO annotations for YDR379C-A
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mitochondrial respiratory chain complex II assembly (IMP)
Cellular Component
High-throughput	mitochondrion (IDA)

Mutant phenotypes All YDR379C-A Phenotype evidence and references

Classical genetics
null	respiratory growth: absent
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All YDR379C-A Interaction evidence and references

	1 total interaction(s) for 1 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All YDR379C-A Protein evidence and references

Localization	YeastRC \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| AspGD Homologs \| CGD Homologs \| CandidaDB Homologs \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrIV:1233517 to 1233278 | |

Note: this feature is encoded on the Crick strand.

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 2001-02-26

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..240	1233517..1233278	2011-02-03	2001-02-26

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000007605

References cited on this page View Complete Literature Guide for YDR379C-A

1)	Ghezzi D, et al. (2009) SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy. Nat Genet 41(6):654-6