TFB5/YDR079C-A Summary Help

Standard Name TFB5 1
Systematic Name YDR079C-A
Feature Type ORF, Verified
Description Component of RNA polymerase II general transcription factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; relocalizes to the cytosol in response to hypoxia; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair (2, 3, 4, 5)
Chromosomal Location
ChrIV:603811 to 603593 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TFB5 GO evidence and references
  View Computational GO annotations for TFB5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
28 total interaction(s) for 16 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Co-crystal Structure: 3
  • Co-purification: 3
  • Reconstituted Complex: 5
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 1
  • Phenotypic Suppression: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 72
Molecular Weight (Da) 8,232
Isoelectric Point (pI) 4.86
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:603811 to 603593 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2001-02-26
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..219 603811..603593 2011-02-03 2001-02-26
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007603
References cited on this page View Complete Literature Guide for TFB5
1) Ranish. J.A. et al.  (2004) Quantitative proteomic identification of TFB5, a new component of general transcription/DNA repair factor IIH Nature Genetics
2) Ranish JA, et al.  (2004) Identification of TFB5, a new component of general transcription and DNA repair factor IIH. Nat Genet 36(7):707-13
3) Zhou Y, et al.  (2007) Tfb5 interacts with Tfb2 and facilitates nucleotide excision repair in yeast. Nucleic Acids Res 35(3):861-71
4) Ding B, et al.  (2007) Tfb5 is partially dispensable for Rad26 mediated transcription coupled nucleotide excision repair in yeast. DNA Repair (Amst) 6(11):1661-9
5) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30