HUG1/YML058W-A Summary Help

Standard Name HUG1 1
Systematic Name YML058W-A
Feature Type ORF, Verified
Description Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress (1, 2)
Chromosomal Location
ChrXIII:158760 to 158966 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HUG1 GO evidence and references
  View Computational GO annotations for HUG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 8 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
14 total interaction(s) for 12 unique genes/features.
Physical Interactions
  • Biochemical Activity: 1
  • PCA: 11

Genetic Interactions
  • Dosage Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 68
Molecular Weight (Da) 7,514
Isoelectric Point (pI) 8.42
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:158760 to 158966 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1998-11-10 | Sequence: 1998-11-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..207 158760..158966 1998-11-10 1998-11-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007472
References cited on this page View Complete Literature Guide for HUG1
1) Basrai MA, et al.  (1999) NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae. Mol Cell Biol 19(10):7041-9
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76