tL(UAA)Q Summary

tL(UAA)Q Summary

Systematic Name	tL(UAA)Q
Feature Type	tRNA
Description	Mitochondrial leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis; required for mitochondrial translation and indirectly for maintenance of the mitochondrial genome; mutations in the orthologous human gene cause the neurological disease MELAS (1, 2, 3)

Chromosomal Location	ChrMito:66095 to 66179 \| ORF Map \| GBrowse

Gene Ontology Annotations All tL(UAA)Q GO evidence and references


Molecular Function
Manually curated	triplet codon-amino acid adaptor activity (ISS)
Biological Process
Manually curated	mitochondrial translation (IMP) translational elongation (IMP)
Cellular Component
Manually curated	mitochondrion (IMP)

Mutant phenotypes All tL(UAA)Q Phenotype evidence and references

Classical genetics
null	mitochondrial genome maintenance: absent respiratory growth: absent
reduction of function	respiratory growth: absent

interactions All tL(UAA)Q Interaction evidence and references

	2 total interaction(s) for 1 unique genes/features.
Physical Interactions	Protein-RNA: 1
Genetic Interactions	Dosage Rescue: 1
Resources	BioGRID

sequence information

ChrMito:66095 to 66179 | |

SGD ORF map

Last Update

Coordinates: 2000-05-19 | Sequence: 2000-05-19

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
Noncoding exon	1..85	66095..66179	2000-05-19	2000-05-19

Retrieve sequences

Analyze Sequence

S288C only	ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes
S288C vs. other species	BLASTN vs. fungi

Resources

External Links	All Associated Seq \| Search all NCBI (Entrez)

Primary SGDID	S000007324

References cited on this page View Complete Literature Guide for tL(UAA)Q

1)	Foury F, et al. (1998) The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae. FEBS Lett 440(3):325-31
2)	Feuermann M, et al. (2003) The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu. EMBO Rep 4(1):53-8
3)	Chan PP and Lowe TM (2009) GtRNAdb: a database of transfer RNA genes detected in genomic sequence. Nucleic Acids Res 37(Database issue):D93-7