AI1/Q0050 Summary

Standard Name	AI1
Systematic Name	Q0050
Feature Type	ORF, Verified
Description	Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene (1, 2, 3)

Chromosomal Location	ChrMito:13818 to 16322 \| ORF Map \| GBrowse

	View Computational GO annotations for AI1
Molecular Function
Manually curated	endonuclease activity (TAS) nucleic acid binding (TAS)
Biological Process
Manually curated	cellular respiration (IMP) homing of group II introns (IDA) mRNA processing (IDA)
Cellular Component
Manually curated	mitochondrion (TAS)

	6 total interaction(s) for 6 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Localization	YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP
Homologs	Ashbya (AGD) \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrMito:13818 to 16322 | |

This feature is contained within: COX1

This feature is contained within: AI2

This feature is contained within: AI3

This feature is contained within: AI4

This feature is contained within: AI5_ALPHA

Last Update

Coordinates: 2000-05-19 | Sequence: 2000-05-19

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2505	13818..16322	2000-05-19	2000-05-19

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000007261

1)	Moran JV, et al. (1994) Splicing defective mutants of the COXI gene of yeast mitochondrial DNA: initial definition of the maturase domain of the group II intron aI2. Nucleic Acids Res 22(11):2057-64
2)	Kennell JC, et al. (1993) Reverse transcriptase activity associated with maturase-encoding group II introns in yeast mitochondria. Cell 73(1):133-46
3)	Moran JV, et al. (1995) Mobile group II introns of yeast mitochondrial DNA are novel site-specific retroelements. Mol Cell Biol 15(5):2828-38