Standard Name	MBF1
Systematic Name	YOR298C-A
Alias	SUF13
Feature Type	ORF, Verified
Description	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description	Multiprotein Bridging Factor 4

Chromosomal Location	ChrXV:877685 to 877230 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 165 cM

	View Computational GO annotations for MBF1
Molecular Function
Manually curated	transcription coactivator activity (IDA)
Biological Process
Manually curated	positive regulation of transcription from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	nucleus (IC)
High-throughput	mitochondrion (IDA)

Resources	YeTFaSCo

Classical genetics
null	resistance to amitrole: decreased viable
Large-scale survey
null	acid pH resistance: decreased glycogen accumulation: increased competitive fitness: decreased resistance to cycloheximide: decreased resistance to glycolaldehyde: decreased resistance to St. John's Wort extract: decreased resistance to benzo[a]pyrene: increased resistance to boric acid: decreased resistance to quinine: decreased resistance to ethanol: decreased starvation resistance: decreased stress resistance: decreased toxin resistance: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	78 total interaction(s) for 68 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 4 Affinity Capture-Western: 2 Biochemical Activity: 1 PCA: 2 Protein-RNA: 1 Reconstituted Complex: 3 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 46 Phenotypic Enhancement: 2 Positive Genetic: 6 Synthetic Growth Defect: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:877685 to 877230 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 165 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 2004-02-12
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..456 877685..877230 2011-02-03 2004-02-12
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000007253