STF1/YDL130W-A Summary Help

Standard Name STF1 1
Systematic Name YDL130W-A
Alias AIS2
Feature Type ORF, Verified
Description Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress; STF1 has a paralog, INH1, that arose from the whole genome duplication (2, 3, 4)
Name Description STabilizing Factor 5, 6
Chromosomal Location
ChrIV:229171 to 229431 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All STF1 GO evidence and references
  View Computational GO annotations for STF1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
43 total interaction(s) for 33 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 4
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 11

Genetic Interactions
  • Negative Genetic: 25

Resources
Expression Summary
histogram
Resources
Length (a.a.) 86
Molecular Weight (Da) 10,062
Isoelectric Point (pI) 10.67
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:229171 to 229431 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1999-07-17 | Sequence: 1999-07-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..261 229171..229431 1999-07-17 1999-07-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007232
References cited on this page View Complete Literature Guide for STF1
1) Akashi A, et al.  (1988) Molecular cloning and expression of a gene for a factor which stabilizes formation of inhibitor-mitochondrial ATPase complex from Saccharomyces cerevisiae. J Biochem (Tokyo) 104(4):526-30
2) Dienhart M, et al.  (2002) Formation of the yeast F1F0-ATP synthase dimeric complex does not require the ATPase inhibitor protein, Inh1. J Biol Chem 277(42):39289-95
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Hashimoto T, et al.  (1983) Binding properties of an intrinsic ATPase inhibitor and occurrence in yeast mitochondria of a protein factor which stabilizes and facilitates the binding of the inhibitor to F1F0-ATPase. J Biochem 94(3):715-20
6) Hashimoto T, et al.  (1984) Purification and properties of factors in yeast mitochondria stabilizing the F1F0-ATPase-inhibitor complex. J Biochem 95(1):131-6