Standard Name	RTC6 1
Systematic Name	YPL183W-A
Alias	TAE4 2
Feature Type	ORF, Verified
Description	Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description	Restriction of Telomere Capping 1

Chromosomal Location	ChrXVI:199095 to 199376 | ORF Map | GBrowse

	View Computational GO annotations for RTC6
Molecular Function
Manually curated	structural constituent of ribosome (ISA)
Biological Process
Manually curated	mitochondrial translation (ISA) ribosome biogenesis (IGI, IMP)
Cellular Component
Manually curated	mitochondrial large ribosomal subunit (ISA)

Retired Name	GON5

Classical genetics
null	tellurium atom accumulation: decreased metal resistance: increased resistance to FK506: decreased resistance to amitrole: decreased resistance to tellurite: increased
Large-scale survey
null	glycogen accumulation: decreased glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased resistance to amitrole: decreased resistance to methyl methanesulfonate: decreased resistance to 4-chlorophenol: decreased resistance to 2,4-dichlorophenol: decreased resistance to cycloheximide: decreased respiratory growth: absent respiratory growth: decreased rate sporulation: absent vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	132 total interaction(s) for 108 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3
Genetic Interactions	Dosage Rescue: 18 Negative Genetic: 76 Positive Genetic: 3 Synthetic Growth Defect: 28 Synthetic Lethality: 1 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:199095 to 199376 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1999-07-17
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..282 199095..199376 2011-02-03 1999-07-17
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000007224