SUP61/tS(CGA)C Summary Help

Standard Name SUP61 1
Systematic Name tS(CGA)C
Feature Type tRNA
Description Serine tRNA (tRNA-Ser), predicted by tRNAscan-SE analysis; i6A37 modification is catalyzed by Mod5p; can mutate to suppress amber or ochre nonsense mutations; suppressor mutant alleles are recessive lethal and can only be maintained when an additional wild-type copy of the gene is present, because SUP61 encodes the only tRNA species that can decode UCG codons (2, 3, 4, 5)
Name Description SUPpressor
Chromosomal Location
ChrIII:227942 to 228042 | ORF Map | GBrowse
Genetic position: 68 cM
Gene Ontology Annotations All SUP61 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
gain of function
Large-scale survey
2 total interaction(s) for 2 unique genes/features.
Genetic Interactions
  • Synthetic Lethality: 2

sequence information
ChrIII:227942 to 228042 | ORF Map | GBrowse
Genetic position: 68 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2000-05-19
Subfeature details
Most Recent Updates
Coordinates Sequence
Noncoding exon 1..37 227942..227978 2011-02-03 2000-05-19
Intron 38..56 227979..227997 2011-02-03 2000-05-19
Noncoding exon 57..101 227998..228042 2011-02-03 2000-05-19
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
External Links All Associated Seq | Search all NCBI (Entrez)
Primary SGDIDS000006730
References cited on this page View Complete Literature Guide for SUP61
1) Hawthorne DC and Leupold U  (1974) Suppressors in yeast. Curr Top Microbiol Immunol 64(0):1-47
2) Etcheverry T, et al.  (1982) Recessive lethality of yeast strains carrying the SUP61 suppressor results from loss of a transfer RNA with a unique decoding function. J Mol Biol 158(4):599-618
3) Brandriss MC, et al.  (1975) Recessive lethal amber suppressors in yeast. Genetics 79(4):551-60
4) Lamichhane TN, et al.  (2011) Plasticity and diversity of tRNA anticodon determinants of substrate recognition by eukaryotic A37 isopentenyltransferases. RNA 17(10):1846-57
5) Chan PP and Lowe TM  (2009) GtRNAdb: a database of transfer RNA genes detected in genomic sequence. Nucleic Acids Res 37(Database issue):D93-7