Standard Name	ARR3 (see Nomenclature conflict Note)
Systematic Name	YPR201W
Alias	ACR3 1
Feature Type	ORF, Verified
Description	Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite (2, 3)
Name Description	ARsenicals Resistance

Chromosomal Location	ChrXVI:939922 to 941136 | ORF Map | GBrowse

	View Computational GO annotations for ARR3
Molecular Function
Manually curated	antimonite transmembrane transporter activity (IMP) antiporter activity (IMP) arsenite transmembrane transporter activity (IGI, ISS)
Biological Process
Manually curated	antimonite transport (IMP) arsenite transport (IGI)
Cellular Component
Manually curated	plasma membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	cell cycle progression in G1 phase: delayed arsenic accumulation: increased resistance to sodium arsenate: decreased resistance to antimonite: decreased resistance to arsenite(3-): decreased
overexpression	resistance to antimonite: increased resistance to arsenite(3-): increased resistance to sodium arsenate: normal resistance to sodium metaarsenite: increased
Large-scale survey
null	auxotrophy competitive fitness: decreased haploproficient hyperosmotic stress resistance: decreased resistance to sodium arsenite: decreased stress resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	27 total interaction(s) for 20 unique genes/features.
Physical Interactions	PCA: 10 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 2 Phenotypic Enhancement: 3 Positive Genetic: 1 Synthetic Growth Defect: 5 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:939922 to 941136 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1215 939922..941136 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000006405