ARR1/YPR199C Summary Help

Standard Name ARR1
Systematic Name YPR199C
Alias YAP8 1 , ACR1 2
Feature Type ORF, Verified
Description Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds (2, 3, 4)
Name Description ARsenicals Resistance
Chromosomal Location
ChrXVI:939032 to 938148 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ARR1 GO evidence and references
  View Computational GO annotations for ARR1
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Targets 14 genes
Regulators 2 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
61 total interaction(s) for 53 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3
  • Co-purification: 1
  • FRET: 1
  • PCA: 1
  • Two-hybrid: 43

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 4
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 294
Molecular Weight (Da) 33,227
Isoelectric Point (pI) 8.05
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:939032 to 938148 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..885 939032..938148 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006403
References cited on this page View Complete Literature Guide for ARR1
1) Fernandes L, et al.  (1997) Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol 17(12):6982-93
2) Bobrowicz P, et al.  (1997) Isolation of three contiguous genes, ACR1, ACR2 and ACR3, involved in resistance to arsenic compounds in the yeast Saccharomyces cerevisiae. Yeast 13(9):819-28
3) Bouganim N, et al.  (2001) Yap1 overproduction restores arsenite resistance to the ABC transporter deficient mutant ycf1 by activating ACR3 expression. Biochem Cell Biol 79(4):441-8
4) Bobrowicz P and Ulaszewski S  (1998) Arsenical - induced transcriptional activation of the yeast Saccharomyces cerevisiae ACR2 and ACR3 genes requires the presence of the ACR1 gene product. Cell Mol Biol Lett 3:13-20
5) Wysocki R, et al.  (2004) Transcriptional activation of metalloid tolerance genes in Saccharomyces cerevisiae requires the AP-1-like proteins Yap1p and Yap8p. Mol Biol Cell 15(5):2049-60