HDA3/YPR179C Summary

HDA3 BASIC INFORMATION

Standard Name	HDA3
Systematic Name	YPR179C
Alias	PLO1
Feature Type	ORF, Verified
Description	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p (1, 2)
Name Description	Histone DeAcetylase 2

GO Annotations	All HDA3 GO evidence and references
	View Computational GO annotations for HDA3
Molecular Function
Manually curated	chromatin binding (IDA) DNA binding (IDA) contributes_to histone deacetylase activity (IDA)
Biological Process
Manually curated	chromosome segregation (IMP) gene silencing by RNA (IMP) gene silencing involved in chronological cell aging (IMP) histone deacetylation (IDA, IMP) negative regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	HDA1 complex (IDA, IPI)
High-throughput	nucleus (IDA)

Mutant Phenotype	All HDA3 Phenotype details and references
Classical genetics
null	histone H2B and H3 modification: increased silencing: increased
Large-scale survey
null	resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased viable

Interactions	HDA3 All interactions details and references
	102 total interaction(s) for 84 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 1 Affinity Capture-Western: 4 PCA: 1 Reconstituted Complex: 2
Genetic Interactions	Synthetic Growth Defect: 28 Synthetic Lethality: 25 Synthetic Rescue: 30

Sequence Information

ChrXVI:895760 to 893793 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1968	895760..893793	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006383

HDA3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for HDA3

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
CDC5	Nomenclature conflict	CDC5/YMR001C encodes a Polo-like kinase and is homologous to the pombe plo1 gene. Do not confuse CDC5/YMR001C with the cerevisiae HDA3 gene, which has been referred to in the cerevisiae literature as PLO1.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HDA3]

1)	Carmen AA, et al. (1996) HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex. J Biol Chem 271(26):15837-44
2)	Wu J, et al. (2001) HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1. Proc Natl Acad Sci U S A 98(8):4391-6

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