DPB2/YPR175W Summary

DPB2 BASIC INFORMATION

Standard Name	DPB2
Systematic Name	YPR175W
Feature Type	ORF, Verified
Description	Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate (1)
Name Description	DNA Polymerase B (II) subunit

GO Annotations	All DPB2 GO evidence and references
	View Computational GO annotations for DPB2
Molecular Function
Manually curated	DNA-directed DNA polymerase activity (TAS) contributes_to double-stranded DNA binding (IDA)
Biological Process
Manually curated	lagging strand elongation (TAS) leading strand elongation (TAS) mismatch repair (TAS) nucleotide-excision repair (TAS)
Cellular Component
Manually curated	cytoplasm (IDA) epsilon DNA polymerase complex (IDA) nucleus (IDA) replication fork (TAS)

Mutant Phenotype	All DPB2 Phenotype details and references
Large-scale survey
null	inviable
repressible	cell cycle progression in S phase: abnormal

Interactions	DPB2 All interactions details and references
	96 total interaction(s) for 48 unique genes/features.
Physical Interactions	Affinity Capture-MS: 52 Affinity Capture-Western: 7 Biochemical Activity: 3 Co-crystal Structure: 1 Co-fractionation: 1 Co-purification: 3 Reconstituted Complex: 3 Two-hybrid: 16
Genetic Interactions	Dosage Rescue: 3 Phenotypic Enhancement: 2 Synthetic Growth Defect: 2 Synthetic Lethality: 3

Sequence Information

ChrXVI:888970 to 891039 | |

Last Update

Coordinates: 2004-07-21 | Sequence: 2003-09-22

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2070	888970..891039	2004-07-21	2003-09-22

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006379

DPB2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for DPB2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DPB2]

1)	Araki H, et al. (1991) DPB2, the gene encoding DNA polymerase II subunit B, is required for chromosome replication in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88(11):4601-5

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