MMS1/YPR164W Summary

MMS1 BASIC INFORMATION

Standard Name	MMS1 1
Systematic Name	YPR164W
Alias	RTT108 2 , SLM6
Feature Type	ORF, Verified
Description	Subunit of an E3 ubiquitin ligase complex involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay (2, 3, 4, 5, 6, 7)
Name Description	Methyl MethaneSulfonate sensitivity

GO Annotations	All MMS1 GO evidence and references
	View Computational GO annotations for MMS1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	negative regulation of transposition, RNA-mediated (IMP) nonfunctional rRNA decay (IMP) recombinational repair (IMP) replication fork processing (IMP)
Cellular Component
Manually curated	cellular_component unknown (ND)

Mutant Phenotype	All MMS1 Phenotype details and references
Classical genetics
null	bud morphology: abnormal chromosome/plasmid maintenance: abnormal colony sectoring: increased gamma ray resistance: normal mitotic recombination: decreased mitotic recombination: normal Rad53p modification: increased resistance to methyl methanesulfonate: decreased resistance to camptothecin: decreased transposable element transposition: increased
reduction of function	UV resistance: normal X ray resistance: normal resistance to methyl methanesulfonate: decreased
Large-scale survey
null	competitive fitness: decreased mitotic recombination: increased Rad52-YFP distribution: increased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to doxorubicin: decreased transposable element transposition: increased viable

Interactions	MMS1 All interactions details and references
	150 total interaction(s) for 112 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-Western: 1 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 1 Phenotypic Enhancement: 52 Phenotypic Suppression: 14 Synthetic Growth Defect: 62 Synthetic Lethality: 11 Synthetic Rescue: 2

Sequence Information

ChrXVI:870699 to 874922 | |

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..4224	870699..874922	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006368

MMS1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MMS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MMS1]

1)	Prakash L and Prakash S (1977) Isolation and characterization of MMS-sensitive mutants of Saccharomyces cerevisiae. Genetics 86(1):33-55
2)	Scholes DT, et al. (2001) Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Genetics 159(4):1449-65
3)	Hryciw T, et al. (2002) MMS1 protects against replication-dependent DNA damage in Saccharomyces cerevisiae. Mol Genet Genomics 266(5):848-57
4)	Araki Y, et al. (2003) Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability. Genes Cells 8(5):465-80
5)	Duro E, et al. (2008) Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage. DNA Repair (Amst) 7(5):811-8
6)	Zaidi IW, et al. (2008) Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA. EMBO Rep 9(10):1034-40
7)	Fujii K, et al. (2009) A role for ubiquitin in the clearance of nonfunctional rRNAs. Genes Dev 23(8):963-74

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.