Standard Name	SGV1 1
Systematic Name	YPR161C
Alias	BUR1 2
Feature Type	ORF, Verified
Description	Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins (2, 3, 4, 5, 6, 7, 8)
Name Description	Suppressor of Gpa1Val50 mutation 1

Chromosomal Location	ChrXVI:866422 to 864449 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SGV1
Molecular Function
Manually curated	cyclin-dependent protein serine/threonine kinase activity (IDA, IPI) RNA polymerase II carboxy-terminal domain kinase activity (IDA)
Biological Process
Manually curated	phosphorylation of RNA polymerase II C-terminal domain (IDA, IMP, IPI) positive regulation of histone H3-K4 methylation (IMP) protein phosphorylation (IDA, IPI) transcription, DNA-dependent (IDA, IMP, IPI)
Cellular Component
Manually curated	cyclin-dependent protein kinase holoenzyme complex (IPI) nucleus (IPI)

Classical genetics
conditional	auxotrophy heat sensitivity: increased
null	inviable
overexpression	budding: abnormal budding index: abnormal cell cycle progression in G2 phase: abnormal
reduction of function	Rpo21p modification: decreased
unspecified	auxotrophy
Large-scale survey
conditional	colony sectoring: increased
null	inviable
overexpression	vegetative growth: decreased
reduction of function	competitive fitness: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	171 total interaction(s) for 130 unique genes/features.
Physical Interactions	Affinity Capture-MS: 86 Affinity Capture-RNA: 2 Affinity Capture-Western: 11 Biochemical Activity: 9 Co-purification: 1 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 4 Negative Genetic: 19 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Growth Defect: 15 Synthetic Lethality: 10 Synthetic Rescue: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:866422 to 864449 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1974 866422..864449 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006365