KRE6/YPR159W Summary Help

Standard Name KRE6 1
Systematic Name YPR159W
Alias CWH48
Feature Type ORF, Verified
Description Type II integral membrane protein; required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication (2, 3, 4)
Name Description Killer toxin REsistant 5
Chromosomal Location
ChrXVI:857583 to 859745 | ORF Map | GBrowse
Gbrowse
Genetic position: 95.9 cM
Gene Ontology Annotations All KRE6 GO evidence and references
  View Computational GO annotations for KRE6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
unspecified
Resources
88 total interaction(s) for 71 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 21
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 5
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 16
  • Synthetic Lethality: 28
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 720
Molecular Weight (Da) 80,122
Isoelectric Point (pI) 4.34
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:857583 to 859745 | ORF Map | GBrowse
SGD ORF map
Genetic position: 95.9 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2163 857583..859745 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006363
References cited on this page View Complete Literature Guide for KRE6
1) Roemer T and Bussey H  (1991) Yeast beta-glucan synthesis: KRE6 encodes a predicted type II membrane protein required for glucan synthesis in vivo and for glucan synthase activity in vitro. Proc Natl Acad Sci U S A 88(24):11295-9
2) Roemer T, et al.  (1993) SKN1 and KRE6 define a pair of functional homologs encoding putative membrane proteins involved in beta-glucan synthesis. Mol Cell Biol 13(7):4039-48
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Kurita T, et al.  (2011) Kre6 Protein Essential for Yeast Cell Wall {beta}-1,6-Glucan Synthesis Accumulates at Sites of Polarized Growth. J Biol Chem 286(9):7429-38
5) Al-Aidroos K and Bussey H  (1978) Chromosomal mutants of Saccharomyces cerevisiae affecting the cell wall binding site for killer factor. Can J Microbiol 24(3):228-37