KRE6/YPR159W Summary

KRE6 BASIC INFORMATION

Standard Name	KRE6 1
Systematic Name	YPR159W
Alias	CWH48
Feature Type	ORF, Verified
Description	Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p (2)
Name Description	Killer toxin REsistant 3

GO Annotations	All KRE6 GO evidence and references
	View Computational GO annotations for KRE6
Molecular Function
Manually curated	glucosidase activity (IMP, ISS)
Biological Process
Manually curated	1,6-beta-glucan biosynthetic process (IMP, ISS) fungal-type cell wall organization (IMP)
Cellular Component
Manually curated	Golgi cis cisterna (IDA) integral to endoplasmic reticulum membrane (IDA) integral to membrane (IDA)

Mutant Phenotype	All KRE6 Phenotype details and references
Classical genetics
null	carboxypeptidase Y (Prc1p) modification: decreased resistance to FK506: decreased
unspecified	killer toxin resistance: decreased resistance to Calcofluor White: decreased
Large-scale survey
null	budding pattern: abnormal cell shape: abnormal polyphosphate accumulation: abnormal competitive fitness: decreased fermentative growth: decreased rate resistance to rapamycin: decreased resistance to wortmannin: normal resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to monensin: decreased resistance to L-1,4-dithiothreitol: decreased resistance to tunicamycin: decreased resistance to doxorubicin: decreased viable

Interactions	KRE6 All interactions details and references
	63 total interaction(s) for 55 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-Western: 4 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 4 Phenotypic Enhancement: 3 Synthetic Growth Defect: 4 Synthetic Lethality: 37 Synthetic Rescue: 2

Sequence Information

ChrXVI:857579 to 859741 | |

Genetic position: 95.9 cM

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2163	857579..859741	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006363

KRE6 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for KRE6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KRE6]

1)	Roemer T and Bussey H (1991) Yeast beta-glucan synthesis: KRE6 encodes a predicted type II membrane protein required for glucan synthesis in vivo and for glucan synthase activity in vitro. Proc Natl Acad Sci U S A 88(24):11295-9
2)	Roemer T, et al. (1993) SKN1 and KRE6 define a pair of functional homologs encoding putative membrane proteins involved in beta-glucan synthesis. Mol Cell Biol 13(7):4039-48
3)	Al-Aidroos K and Bussey H (1978) Chromosomal mutants of Saccharomyces cerevisiae affecting the cell wall binding site for killer factor. Can J Microbiol 24(3):228-37

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