TDA6/YPR157W Summary Help

Standard Name TDA6 1
Systematic Name YPR157W
Feature Type ORF, Uncharacterized
Description Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele; TDA6 has a paralog, VPS62, that arose from the whole genome duplication (1, 2, 3)
Name Description Topoisomerase I Damage Affected 1
Chromosomal Location
ChrXVI:841266 to 842669 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TDA6 GO evidence and references
  View Computational GO annotations for TDA6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Large-scale survey
null
overexpression
Resources
5 total interaction(s) for 5 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Dosage Lethality: 2
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 467
Molecular Weight (Da) 53,809
Isoelectric Point (pI) 7.43
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:841266 to 842669 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1404 841266..842669 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006361
References cited on this page View Complete Literature Guide for TDA6
1) Reid RJ, et al.  (2011) Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res 21(3):477-86
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Dardalhon M, et al.  (2007) Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast. FEMS Yeast Res 7(6):866-878