TDA6/YPR157W Summary Help

Standard Name TDA6 1
Systematic Name YPR157W
Feature Type ORF, Uncharacterized
Description Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele; TDA6 has a paralog, VPS62, that arose from the whole genome duplication (1, 2, 3)
Name Description Topoisomerase I Damage Affected 1
Chromosomal Location
ChrXVI:841266 to 842669 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TDA6 GO evidence and references
  View Computational GO annotations for TDA6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 59 genes
Resources
Large-scale survey
null
overexpression
Resources
5 total interaction(s) for 5 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Dosage Lethality: 2
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 467
Molecular Weight (Da) 53,809
Isoelectric Point (pI) 7.43
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:841266 to 842669 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1404 841266..842669 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006361
References cited on this page View Complete Literature Guide for TDA6
1) Reid RJ, et al.  (2011) Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res 21(3):477-86
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Dardalhon M, et al.  (2007) Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast. FEMS Yeast Res 7(6):866-878