LOA1/YPR139C Summary Help

Standard Name LOA1 1
Systematic Name YPR139C
Alias VPS66 2
Feature Type ORF, Verified
Description Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA (1, 3)
Name Description Lysophosphatidic acid: Oleoyl-CoA Acyltransferase 1
Chromosomal Location
ChrXVI:814058 to 813156 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All LOA1 GO evidence and references
  View Computational GO annotations for LOA1
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
24 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 3
  • Co-localization: 4
  • Co-purification: 1
  • PCA: 1
  • Protein-peptide: 2
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 300
Molecular Weight (Da) 33,816
Isoelectric Point (pI) 10.5
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:814058 to 813156 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..903 814058..813156 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006343
References cited on this page View Complete Literature Guide for LOA1
1) Ayciriex S, et al.  (2012) YPR139c/LOA1 encodes a novel lysophosphatidic acid acyltransferase associated with lipid droplets and involved in TAG homeostasis. Mol Biol Cell 23(2):233-46
2) Bonangelino CJ, et al.  (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501
3) Grillitsch K, et al.  (2011) Lipid particles/droplets of the yeast Saccharomyces cerevisiae revisited: lipidome meets proteome. Biochim Biophys Acta 1811(12):1165-76