CTF4/YPR135W Summary

CTF4 BASIC INFORMATION

Standard Name	CTF4 1
Systematic Name	YPR135W
Alias	CHL15 , POB1
Feature Type	ORF, Verified
Description	Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion (2, 3)
Name Description	Chromosome Transmission Fidelity 1

GO Annotations	All CTF4 GO evidence and references
	View Computational GO annotations for CTF4
Molecular Function
Manually curated	DNA binding (ISS)
Biological Process
Manually curated	DNA repair (IGI, IMP) DNA-dependent DNA replication (IMP, IPI) mitotic sister chromatid cohesion (IGI, IMP) replicative cell aging (IMP)
Cellular Component
Manually curated	nuclear chromosome (IDA) nuclear replication fork (IDA) nucleus (IPI) replication fork protection complex (IDA)

Mutant Phenotype	All CTF4 Phenotype details and references
Classical genetics
null	chromosome segregation: abnormal colony sectoring: increased lifespan: decreased GFP-Rap1 distribution: abnormal resistance to hydroxyurea: decreased resistance to Calcofluor White: decreased transposable element transposition: increased
Large-scale survey
null	UV resistance: decreased bud morphology: abnormal budding index: increased glycogen accumulation: decreased chromosome/plasmid maintenance: decreased competitive fitness: decreased fermentative growth: decreased rate freeze-thaw resistance: decreased metal resistance: decreased mitotic recombination: increased Rad52-YFP distribution: increased resistance to cycloheximide: decreased resistance to hygromycin B: decreased resistance to rapamycin: decreased resistance to cadmium dichloride: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to cisplatin: decreased resistance to benomyl: decreased resistance to doxorubicin: decreased toxin resistance: decreased vegetative growth: absent viable

Interactions	CTF4 All interactions details and references
	556 total interaction(s) for 278 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 1 Affinity Capture-Western: 9 Biochemical Activity: 5 Co-purification: 4 Reconstituted Complex: 6 Two-hybrid: 7
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Dosage Rescue: 2 Phenotypic Enhancement: 96 Phenotypic Suppression: 19 Synthetic Growth Defect: 205 Synthetic Lethality: 184 Synthetic Rescue: 3

Sequence Information

ChrXVI:799230 to 802013 | |

Genetic position: 103 cM

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2784	799230..802013	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006339

CTF4 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CTF4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CTF4]

1)	Spencer F, et al. (1990) Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124(2):237-49
2)	Miles J and Formosa T (1992) Evidence that POB1, a Saccharomyces cerevisiae protein that binds to DNA polymerase alpha, acts in DNA metabolism in vivo. Mol Cell Biol 12(12):5724-35
3)	Hanna JS, et al. (2001) Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion. Mol Cell Biol 21(9):3144-58

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.