Standard Name	PIS1
Systematic Name	YPR113W
Feature Type	ORF, Verified
Description	Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins (1, 2)
Name Description	Phosphatidyl Inositol Synthase 3

Chromosomal Location	ChrXVI:752257 to 752919 | ORF Map | GBrowse

	View Computational GO annotations for PIS1
Molecular Function
Manually curated	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity (IDA, IMP)
Biological Process
Manually curated	phosphatidylinositol biosynthetic process (IDA, IMP)
Cellular Component
Manually curated	Golgi apparatus (IDA) integral to membrane (IDA) mitochondrial outer membrane (IDA)
High-throughput	integral to membrane (ISM) mitochondrion (IDA)

Pathways	phosphatidylinositol biosynthesis superpathway of phospholipid biosynthesis

Classical genetics
null	cell cycle progression: arrested inviable
repressible	phosphatidylcholine accumulation: increased phosphatidylinositol accumulation: decreased
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	48 total interaction(s) for 47 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 3 PCA: 23 Two-hybrid: 10
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 5 Positive Genetic: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:752257 to 752919 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..663 752257..752919 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006317