PIS1/YPR113W Summary Help

Standard Name PIS1 1
Systematic Name YPR113W
Feature Type ORF, Verified
Description Phosphatidylinositol synthase; required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins (2, 3)
Name Description Phosphatidyl Inositol Synthase 1
Chromosomal Location
ChrXVI:752257 to 752919 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PIS1 GO evidence and references
  View Computational GO annotations for PIS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Pathways
Classical genetics
null
repressible
Large-scale survey
null
overexpression
reduction of function
unspecified
Resources
52 total interaction(s) for 50 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 1
  • PCA: 23
  • Two-hybrid: 11

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 5
  • Positive Genetic: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 220
Molecular Weight (Da) 24,823
Isoelectric Point (pI) 8.92
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:752257 to 752919 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..663 752257..752919 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006317
References cited on this page View Complete Literature Guide for PIS1
1) Nikawa J and Yamashita S  (1984) Molecular cloning of the gene encoding CDPdiacylglycerol-inositol 3-phosphatidyl transferase in Saccharomyces cerevisiae. Eur J Biochem 143(2):251-6
2) Nikawa J, et al.  (1987) Primary structure and disruption of the phosphatidylinositol synthase gene of Saccharomyces cerevisiae. J Biol Chem 262(10):4876-81
3) Nikawa J and Yamashita S  (1997) Phosphatidylinositol synthase from yeast. Biochim Biophys Acta 1348(1-2):173-8