RPN7/YPR108W Summary

RPN7 BASIC INFORMATION

Standard Name	RPN7 1
Systematic Name	YPR108W
Feature Type	ORF, Verified
Description	Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits (2)
Name Description	Regulatory Particle Non-ATPase 1

GO Annotations	All RPN7 GO evidence and references
	View Computational GO annotations for RPN7
Molecular Function
Manually curated	structural molecule activity (IMP)
Biological Process
Manually curated	ubiquitin-dependent protein catabolic process (TAS)
Cellular Component
Manually curated	nucleus (IDA) proteasome regulatory particle, lid subcomplex (IPI)

Mutant Phenotype	All RPN7 Phenotype details and references
Classical genetics
conditional	cell cycle progression through the G2/M phase transition: abnormal cell size: increased heat sensitivity: increased polyubiquitinated proteins accumulation: increased polyubiquinated proteins accumulation: increased Pds1p accumulation: increased Clb2p accumulation: increased
Large-scale survey
null	inviable

Interactions	RPN7 All interactions details and references
	165 total interaction(s) for 46 unique genes/features.
Physical Interactions	Affinity Capture-MS: 89 Affinity Capture-Western: 23 Co-purification: 3 Two-hybrid: 4
Genetic Interactions	Synthetic Growth Defect: 26 Synthetic Rescue: 20

Sequence Information

ChrXVI:742452 to 743741 | |

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1290	742452..743741	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006312

RPN7 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RPN7

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RPN7]

1)	Finley D, et al. (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2)	Glickman MH, et al. (1998) The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol 18(6):3149-62

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