COG4/YPR105C Summary Help

Standard Name COG4 1
Systematic Name YPR105C
Alias COD1 , SEC38 1 , SGF1 2
Feature Type ORF, Verified
Description Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments (1, 3)
Name Description Conserved Oligomeric Golgi complex 1
Chromosomal Location
ChrXVI:739569 to 736984 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All COG4 GO evidence and references
  View Computational GO annotations for COG4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
repressible
Large-scale survey
null
reduction of function
Resources
161 total interaction(s) for 112 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 32
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 15
  • Biochemical Activity: 2
  • PCA: 2
  • Two-hybrid: 23

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 11
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1
  • Synthetic Rescue: 66

Resources
Expression Summary
histogram
Resources
Length (a.a.) 861
Molecular Weight (Da) 98,665
Isoelectric Point (pI) 6.01
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:739569 to 736984 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2586 739569..736984 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006309
References cited on this page View Complete Literature Guide for COG4
1) Ram RJ, et al.  (2002) Identification of Sec36p, Sec37p, and Sec38p: components of yeast complex that contains Sec34p and Sec35p. Mol Biol Cell 13(5):1484-500
2) Kim DW, et al.  (2001) Sgf1p, a new component of the Sec34p/Sec35p complex. Traffic 2(11):820-30
3) Loh E and Hong W  (2004) The binary interacting network of the conserved oligomeric Golgi tethering complex. J Biol Chem 279(23):24640-8