TEF1/YPR080W Summary Help

Standard Name TEF1 1
Systematic Name YPR080W
Feature Type ORF, Verified
Description Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF1 has a paralog, TEF2, that arose from the whole genome duplication (1, 2, 3)
Also known as: EF-1 alpha
Name Description Translation Elongation Factor 1
Gene Product Alias eEF1A 4
Chromosomal Location
ChrXVI:700594 to 701970 | ORF Map | GBrowse
Genetic position: 46 cM
Gene Ontology Annotations All TEF1 GO evidence and references
  View Computational GO annotations for TEF1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Classical genetics
195 total interaction(s) for 154 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 115
  • Affinity Capture-RNA: 7
  • Affinity Capture-Western: 14
  • Biochemical Activity: 1
  • Co-crystal Structure: 2
  • Co-fractionation: 4
  • Co-purification: 2
  • PCA: 3
  • Reconstituted Complex: 4

Genetic Interactions
  • Dosage Rescue: 8
  • Negative Genetic: 15
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 4
  • Positive Genetic: 5
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 1

Expression Summary
Length (a.a.) 458
Molecular Weight (Da) 50,032
Isoelectric Point (pI) 9.72
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXVI:700594 to 701970 | ORF Map | GBrowse
Genetic position: 46 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1377 700594..701970 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006284
References cited on this page View Complete Literature Guide for TEF1
1) Schirmaier F and Philippsen P  (1984) Identification of two genes coding for the translation elongation factor EF-1 alpha of S. cerevisiae. EMBO J 3(13):3311-5
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Murthi A, et al.  (2010) Regulation of tRNA Bidirectional Nuclear-Cytoplasmic Trafficking in Saccharomyces cerevisiae. Mol Biol Cell 21(4):639-49
4) Carr-Schmid A, et al.  (1999) Mutations in a GTP-binding motif of eukaryotic elongation factor 1A reduce both translational fidelity and the requirement for nucleotide exchange. J Biol Chem 274(42):30297-302