ROX1/YPR065W Summary

ROX1 BASIC INFORMATION

Standard Name	ROX1 1
Systematic Name	YPR065W
Alias	REO1 2 , 3
Feature Type	ORF, Verified
Description	Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity (4, 5, 6, 7)
Name Description	Regulation by OXygen 1

GO Annotations	All ROX1 GO evidence and references
	View Computational GO annotations for ROX1
Molecular Function
Manually curated	DNA bending activity (IDA) sequence-specific DNA binding (IDA) specific transcriptional repressor activity (IGI, IMP)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	negative regulation of gene-specific transcription from RNA polymerase II promoter (IMP) negative regulation of transcription from RNA polymerase II promoter (IGI, IMP)
Cellular Component
Manually curated	nuclear chromosome (IPI)

Regulatory Role
Binding motifs	ROX1 Transcription Factor Binding Sites and References
	YYYATTGTTCTC

Mutant Phenotype	All ROX1 Phenotype details and references
Classical genetics
null	metal resistance: decreased resistance to 4-nitroquinoline-1-oxide: increased
Large-scale survey
null	metal resistance: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased viable
overexpression	vegetative growth: decreased

Interactions	ROX1 All interactions details and references
	4 total interaction(s) for 4 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 PCA: 1
Genetic Interactions	Phenotypic Enhancement: 1

Sequence Information

ChrXVI:679690 to 680796 | |

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1107	679690..680796	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006269

ROX1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ROX1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ROX1]

1)	Lowry CV and Zitomer RS (1984) Oxygen regulation of anaerobic and aerobic genes mediated by a common factor in yeast. Proc Natl Acad Sci U S A 81(19):6129-33
2)	Kwast KE, et al. (1997) REO1 and ROX1 are alleles of the same gene which encodes a transcriptional repressor of hypoxic genes in Saccharomyces cerevisiae. Curr Genet 32(6):377-83
3)	Trueblood CE and Poyton RO (1988) Identification of REO1, a gene involved in negative regulation of COX5b and ANB1 in aerobically grown Saccharomyces cerevisiae. Genetics 120(3):671-80
4)	Deckert J, et al. (1995) Multiple elements and auto-repression regulate Rox1, a repressor of hypoxic genes in Saccharomyces cerevisiae. Genetics 139(3):1149-58
5)	Keng T (1992) HAP1 and ROX1 form a regulatory pathway in the repression of HEM13 transcription in Saccharomyces cerevisiae. Mol Cell Biol 12(6):2616-23
6)	Deckert J, et al. (1995) Mutational analysis of Rox1, a DNA-bending repressor of hypoxic genes in Saccharomyces cerevisiae. Mol Cell Biol 15(11):6109-17
7)	Ter Linde JJ and Steensma HY (2002) A microarray-assisted screen for potential Hap1 and Rox1 target genes in Saccharomyces cerevisiae. Yeast 19(10):825-40

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