BRR1/YPR057W Summary

BRR1 BASIC INFORMATION

Standard Name	BRR1
Systematic Name	YPR057W
Feature Type	ORF, Verified
Description	snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed (1, 2, 3)
Name Description	Bad Response to Refrigeration 1

GO Annotations	All BRR1 GO evidence and references
	View Computational GO annotations for BRR1
Molecular Function
Manually curated	RNA binding (IPI)
Biological Process
Manually curated	spliceosome assembly (IMP)
Cellular Component
Manually curated	small nuclear ribonucleoprotein complex (IDA)

Mutant Phenotype	All BRR1 Phenotype details and references
Classical genetics
conditional	cold sensitivity: increased
null	spliceosomal snRNAs accumulation: decreased
Large-scale survey
null	bud morphology: abnormal glycogen accumulation: increased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate heat sensitivity: increased resistance to rapamycin: decreased resistance to wortmannin: decreased viable

Interactions	BRR1 All interactions details and references
	View additional details at BioGRID
	210 total interaction(s) for 189 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 1
Genetic Interactions	Negative Genetic: 124 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 61 Synthetic Growth Defect: 7 Synthetic Lethality: 4

Sequence Information

ChrXVI:672468 to 673493 | |

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1026	672468..673493	2004-07-21	1996-07-31

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006261

BRR1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for BRR1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BRR1]

1)	Noble SM and Guthrie C (1996) Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics 143(1):67-80
2)	Noble SM and Guthrie C (1996) Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs. EMBO J 15(16):4368-79
3)	Liu Q, et al. (1997) The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Cell 90(6):1013-21

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