Standard Name	TFB4 1
Systematic Name	YPR056W
Feature Type	ORF, Verified
Description	Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p (1, 2, 3)
Name Description	Transcription Factor B subunit 4 1

Chromosomal Location	ChrXVI:671126 to 672142 | ORF Map | GBrowse

	View Computational GO annotations for TFB4
Molecular Function
Manually curated	contributes_to core RNA polymerase binding transcription factor activity (IC)
Biological Process
Manually curated	nucleotide-excision repair (IMP) phosphorylation of RNA polymerase II C-terminal domain (IDA) transcription from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	core TFIIH complex (IDA) holo TFIIH complex (IDA) nucleotide-excision repair factor 3 complex (IPI)

Classical genetics
conditional	heat sensitivity: increased
null	inviable
reduction of function	UV resistance: decreased auxotrophy
Large-scale survey
null	haploinsufficient inviable starvation resistance: decreased
reduction of function	competitive fitness: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	76 total interaction(s) for 42 unique genes/features.
Physical Interactions	Affinity Capture-MS: 32 Affinity Capture-RNA: 2 Affinity Capture-Western: 15 Co-crystal Structure: 1 Co-purification: 19 PCA: 3 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 1 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:671126 to 672142 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1017 671126..672142 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006260