TFB4/YPR056W Summary

TFB4 BASIC INFORMATION

Standard Name	TFB4 1
Systematic Name	YPR056W
Feature Type	ORF, Verified
Description	Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p (1, 2, 3)
Name Description	Transcription Factor B subunit 4 1

GO Annotations	All TFB4 GO evidence and references
	View Computational GO annotations for TFB4
Molecular Function
Manually curated	general RNA polymerase II transcription factor activity (TAS)
Biological Process
Manually curated	negative regulation of transcription from RNA polymerase II promoter, mitotic (TAS) nucleotide-excision repair (IMP) transcription initiation from RNA polymerase II promoter (TAS)
Cellular Component
Manually curated	core TFIIH complex (IDA) core TFIIH complex portion of holo TFIIH complex (IDA) holo TFIIH complex (IDA) SSL2-core TFIIH complex portion of holo TFIIH complex (IDA) SSL2-core TFIIH complex portion of NEF3 complex (IPI)

Mutant Phenotype	All TFB4 Phenotype details and references
Classical genetics
conditional	heat sensitivity: increased
null	inviable
reduction of function	UV resistance: decreased auxotrophy
Large-scale survey
null	inviable

Interactions	TFB4 All interactions details and references
	47 total interaction(s) for 27 unique genes/features.
Physical Interactions	Affinity Capture-MS: 19 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Co-purification: 16 Reconstituted Complex: 1 Two-hybrid: 4

Sequence Information

ChrXVI:671123 to 672139 | |

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1017	671123..672139	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006260

TFB4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for TFB4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TFB4]

1)	Feaver WJ, et al. (1997) Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunits. J Biol Chem 272(31):19319-27
2)	Feaver WJ, et al. (2000) Subunit interactions in yeast transcription/repair factor TFIIH. Requirement for Tfb3 subunit in nucleotide excision repair. J Biol Chem 275(8):5941-6
3)	Lee TI and Young RA (2000) Transcription of eukaryotic protein-coding genes. Annu Rev Genet 34:77-137

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