SEC8/YPR055W Summary Help

SEC8 BASIC INFORMATION

Standard Name SEC8 1
Systematic Name YPR055W
Feature Type ORF, Verified
Description Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis (2, 3)
Name Description SECretory 4
GO Annotations All SEC8 GO evidence and references
    View Computational GO annotations for SEC8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All SEC8 Phenotype details and references
Classical genetics
conditional
Large-scale survey
null
repressible
Interactions SEC8 All interactions details and references
122 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 25
  • Affinity Capture-Western: 33
  • Co-fractionation: 4
  • Co-purification: 1
  • PCA: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 4
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 3
  • Dosage Rescue: 7
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 37
  • Synthetic Rescue: 2
Sequence Information
ChrXVI:667673 to 670870 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-21 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3198 667673..670870 2004-07-21 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000006259

SEC8 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SEC8

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC8]

1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) TerBush DR, et al.  (1996) The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J 15(23):6483-94
3) TerBush DR and Novick P  (1995) Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J Cell Biol 130(2):299-312
4) Novick P and Schekman R  (1979) Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 76(4):1858-62