NHP6A/YPR052C Summary

NHP6A BASIC INFORMATION

Standard Name	NHP6A
Systematic Name	YPR052C
Feature Type	ORF, Verified
Description	High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters (1)
Name Description	Non-Histone Protein 2

GO Annotations	All NHP6A GO evidence and references
	View Computational GO annotations for NHP6A
Molecular Function
Manually curated	chromatin binding (IDA, IPI)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	chromatin organization (IPI) chromatin remodeling (IMP) nucleosome assembly (IDA) positive regulation of transcription from RNA polymerase II promoter (IMP, IPI) regulation of transcription from RNA polymerase II promoter (IGI, ISS) regulation of transcription from RNA polymerase III promoter (IDA, IGI, IMP)
Cellular Component
Manually curated	nuclear chromatin (IPI)

Mutant Phenotype	All NHP6A Phenotype details and references
Classical genetics
null	NHP6B mRNA accumulation: increased Nhp6Bp accumulation: increased
overexpression	vegetative growth: arrested
Large-scale survey
null	viable

Interactions	NHP6A All interactions details and references
	128 total interaction(s) for 93 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Co-localization: 1 Co-purification: 1 PCA: 4 Reconstituted Complex: 2 Two-hybrid: 30
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 15 Phenotypic Enhancement: 19 Phenotypic Suppression: 12 Synthetic Growth Defect: 13 Synthetic Lethality: 11 Synthetic Rescue: 3

Sequence Information

ChrXVI:665971 to 665690 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..282	665971..665690	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006256

NHP6A RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for NHP6A

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NHP6A]

1)	Fragiadakis GS, et al. (2004) Nhp6 facilitates Aft1 binding and Ssn6 recruitment, both essential for FRE2 transcriptional activation. EMBO J 23(2):333-42
2)	Kolodrubetz D, et al. (1988) Amino-terminal sequence of a Saccharomyces cerevisiae nuclear protein, NHP6, shows significant identity to bovine HMG1. FEBS Lett 238(1):175-9

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.