PUF2/YPR042C Summary

PUF2 BASIC INFORMATION

Standard Name	PUF2
Systematic Name	YPR042C
Feature Type	ORF, Verified
Description	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins (1)
Name Description	PUmilio-homology domain Family 2

GO Annotations	All PUF2 GO evidence and references
	View Computational GO annotations for PUF2
Molecular Function
Manually curated	mRNA binding (ISS)
High-throughput	mRNA binding (IDA)
Biological Process
Manually curated	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (IGI)
Cellular Component
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All PUF2 Phenotype details and references
Large-scale survey
null	viable

Interactions	PUF2 All interactions details and references
	22 total interaction(s) for 21 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 2 Biochemical Activity: 2 PCA: 1 Protein-RNA: 2 Reconstituted Complex: 1
Genetic Interactions	Phenotypic Enhancement: 6 Phenotypic Suppression: 7

Sequence Information

ChrXVI:653659 to 650432 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3228	653659..650432	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006246

PUF2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for PUF2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PUF2]

1)	Gerber AP, et al. (2004) Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS Biol 2(3):E79
2)	Olivas W and Parker R (2000) The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast. EMBO J 19(23):6602-11

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