TIP41/YPR040W Summary Help

Standard Name TIP41 1
Systematic Name YPR040W
Feature Type ORF, Verified
Description Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description Tap42 Interacting Protein 1
Chromosomal Location
ChrXVI:647305 to 648375 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TIP41 GO evidence and references
  View Computational GO annotations for TIP41
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 8 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
65 total interaction(s) for 48 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 5
  • Biochemical Activity: 2
  • PCA: 2
  • Two-hybrid: 8

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 2
  • Negative Genetic: 16
  • Phenotypic Suppression: 2
  • Positive Genetic: 2
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1
  • Synthetic Rescue: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 356
Molecular Weight (Da) 41,019
Isoelectric Point (pI) 7.89
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:647305 to 648375 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1071 647305..648375 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006244
References cited on this page View Complete Literature Guide for TIP41
1) Jacinto E, et al.  (2001) TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Mol Cell 8(5):1017-26
2) Santhanam A, et al.  (2004) PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p. Eukaryot Cell 3(5):1261-71
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76