NTO1/YPR031W Summary Help

Standard Name NTO1 1, 2
Systematic Name YPR031W
Feature Type ORF, Verified
Description Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3 (3, 4)
Name Description NuA Three Orf
Chromosomal Location
ChrXVI:631515 to 633761 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NTO1 GO evidence and references
  View Computational GO annotations for NTO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
87 total interaction(s) for 68 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-Western: 2

Genetic Interactions
  • Negative Genetic: 54
  • Phenotypic Enhancement: 6
  • Positive Genetic: 6
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 748
Molecular Weight (Da) 86,029
Isoelectric Point (pI) 7.53
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:631515 to 633761 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2247 631515..633761 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006235
References cited on this page View Complete Literature Guide for NTO1
1) Howe, L. and Workman, J.  (2002) personal communication
2) Perry J  (2006) The Epc-N domain: a predicted protein-protein interaction domain found in select chromatin associated proteins. BMC Genomics 7:6
3) Shi X, et al.  (2007) Proteome-wide Analysis in Saccharomyces cerevisiae Identifies Several PHD Fingers as Novel Direct and Selective Binding Modules of Histone H3 Methylated at Either Lysine 4 or Lysine 36. J Biol Chem 282(4):2450-5
4) Taverna SD, et al.  (2006) Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell 24(5):785-96