APL4/YPR029C Summary

APL4 BASIC INFORMATION

Standard Name	APL4
Systematic Name	YPR029C
Feature Type	ORF, Verified
Description	Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport (1, 2)
Name Description	clathrin Adaptor Protein complex Large chain

GO Annotations	All APL4 GO evidence and references
	View Computational GO annotations for APL4
Molecular Function
Manually curated	clathrin binding (IPI, ISS)
Biological Process
Manually curated	Golgi to vacuole transport (IMP) vesicle-mediated transport (IPI, ISS)
Cellular Component
Manually curated	AP-1 adaptor complex (IPI, ISS)

Mutant Phenotype	All APL4 Phenotype details and references
Classical genetics
null	vacuolar morphology: abnormal vacuolar transport: abnormal
reduction of function	vacuolar transport: decreased
Large-scale survey
null	viable
overexpression	resistance to rapamycin: decreased

Interactions	APL4 All interactions details and references
	46 total interaction(s) for 21 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 Affinity Capture-Western: 2 Biochemical Activity: 1 Co-purification: 1 PCA: 8 Reconstituted Complex: 2 Two-hybrid: 6
Genetic Interactions	Phenotypic Enhancement: 1 Synthetic Growth Defect: 3 Synthetic Lethality: 1 Synthetic Rescue: 1

Sequence Information

ChrXVI:626964 to 624466 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2499	626964..624466	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006233

APL4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for APL4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for APL4]

1)	Panek HR, et al. (1997) Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex. EMBO J 16(14):4194-204
2)	Kirchhausen T (2000) Three ways to make a vesicle. Nat Rev Mol Cell Biol 1(3):187-98

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