YOP1/YPR028W Summary Help

Standard Name YOP1 1
Systematic Name YPR028W
Alias YIP2
Feature Type ORF, Verified
Description Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress (1, 2, 3, 4, 5)
Name Description YIP One Partner 1
Chromosomal Location
ChrXVI:623527 to 624202 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YOP1 GO evidence and references
  View Computational GO annotations for YOP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 146 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
101 total interaction(s) for 75 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 10
  • Co-purification: 1
  • PCA: 26
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 16
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 4
  • Positive Genetic: 7
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 10

Resources
Expression Summary
histogram
Resources
Length (a.a.) 180
Molecular Weight (Da) 20,269
Isoelectric Point (pI) 9.87
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:623527 to 624202 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..51 623527..623577 2011-02-03 1996-07-31
Intron 52..184 623578..623710 2011-02-03 1996-07-31
CDS 185..676 623711..624202 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006232
References cited on this page View Complete Literature Guide for YOP1
1) Calero M, et al.  (2001) Yop1p, the yeast homolog of the polyposis locus protein 1, interacts with Yip1p and negatively regulates cell growth. J Biol Chem 276(15):12100-12
2) Brands A and Ho TH  (2002) Function of a plant stress-induced gene, HVA22. Synthetic enhancement screen with its yeast homolog reveals its role in vesicular traffic. Plant Physiol 130(3):1121-31
3) Hu J, et al.  (2009) A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell 138(3):549-61
4) Voss C, et al.  (2012) ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae. J Cell Sci 125(Pt 20):4791-9
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76