Standard Name	YOP1 1
Systematic Name	YPR028W
Alias	YIP2
Feature Type	ORF, Verified
Description	Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress (1, 2, 3, 4, 5)
Name Description	YIP One Partner 1

Chromosomal Location	ChrXVI:623527 to 624202 | ORF Map | GBrowse

	View Computational GO annotations for YOP1
Molecular Function
Manually curated	protein binding (IPI)
Biological Process
Manually curated	endoplasmic reticulum inheritance (IGI) endoplasmic reticulum organization (IGI) nuclear pore complex assembly (IGI) vesicle-mediated transport (IMP, IPI)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) endoplasmic reticulum tubular network (IDA) integral to membrane (IDA)
High-throughput	cellular bud tip (IDA) endoplasmic reticulum (IDA)

Classical genetics
null	autophagy: increased
Large-scale survey
null	competitive fitness: decreased competitive fitness: increased haploinsufficient resistance to streptomycin: decreased resistance to cycloheximide: decreased resistance to benzo[a]pyrene: decreased viable
overexpression	filamentous growth: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	99 total interaction(s) for 75 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 3 Affinity Capture-Western: 10 Co-purification: 1 PCA: 26 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 16 Phenotypic Enhancement: 3 Phenotypic Suppression: 4 Positive Genetic: 7 Synthetic Growth Defect: 6 Synthetic Lethality: 10
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:623527 to 624202 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..51 623527..623577 2011-02-03 1996-07-31 Intron 52..184 623578..623710 2011-02-03 1996-07-31 CDS 185..676 623711..624202 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (52 - 184)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006232