YME1/YPR024W Summary Help

Standard Name YME1 1
Systematic Name YPR024W
Alias OSD1 , YTA11 2
Feature Type ORF, Verified
Description Catalytic subunit of the i-AAA protease complex; complex is located in the mitochondrial inner membrane; responsible for degradation of unfolded or misfolded mitochondrial gene products; serves as a nonconventional translocation motor to pull PNPase into the intermembrane space; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover (1, 3, 4, 5, 6, 7)
Name Description Yeast Mitochondrial Escape 1
Chromosomal Location
ChrXVI:610481 to 612724 | ORF Map | GBrowse
Gene Ontology Annotations All YME1 GO evidence and references
  View Computational GO annotations for YME1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Classical genetics
Large-scale survey
562 total interaction(s) for 455 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 10
  • Biochemical Activity: 1
  • Co-purification: 1

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 1
  • Negative Genetic: 240
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 11
  • Positive Genetic: 236
  • Synthetic Growth Defect: 16
  • Synthetic Lethality: 14
  • Synthetic Rescue: 16

Expression Summary
Length (a.a.) 747
Molecular Weight (Da) 81,771
Isoelectric Point (pI) 7.06
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXVI:610481 to 612724 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2244 610481..612724 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006228
References cited on this page View Complete Literature Guide for YME1
1) Thorsness PE and Fox TD  (1993) Nuclear mutations in Saccharomyces cerevisiae that affect the escape of DNA from mitochondria to the nucleus. Genetics 134(1):21-8
2) Schnall R, et al.  (1994) Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex. Yeast 10(9):1141-55
3) Campbell CL and Thorsness PE  (1998) Escape of mitochondrial DNA to the nucleus in yme1 yeast is mediated by vacuolar-dependent turnover of abnormal mitochondrial compartments. J Cell Sci 111 ( Pt 16)():2455-64
4) Leonhard K, et al.  (1999) Chaperone-like activity of the AAA domain of the yeast Yme1 AAA protease. Nature 398(6725):348-51
5) Dunn CD, et al.  (2006) A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex. Mol Biol Cell 17(1):213-26
6) Rainey RN, et al.  (2006) A new function in translocation for the mitochondrial i-AAA protease Yme1: import of polynucleotide phosphorylase into the intermembrane space. Mol Cell Biol 26(22):8488-97
7) Schreiner B, et al.  (2012) Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria. Mol Biol Cell 23(22):4335-46